کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262131 1290791 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportGap junction blockade eliminates supralinear summation of fast (>200 Hz) oscillatory components during sensory integration in the rat barrel cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Research reportGap junction blockade eliminates supralinear summation of fast (>200 Hz) oscillatory components during sensory integration in the rat barrel cortex
چکیده انگلیسی

The vibrissa-barrel system of rodents has become one of the dominant models for studying sensory information processing. Fast oscillations (>200 Hz) have been shown to play an important role in cortical integration of inputs from several whiskers. The mechanism subserving such integration remains, however, unknown. To address this issue, we examined the influence of the gap junction blocker (carbenoxolone, CBX) topically applied on the cortical surface on the high frequency component evoked by multiple-whisker stimulation. The magnitude of the fast oscillatory response to simultaneous stimulation of three whiskers was shown to be higher compared to its linear prediction (defined as the sum of corresponding single whisker responses). Application of CBX eliminated this supra-linear enhancement of fast oscillations. These results indicate that gap junctions are involved in the synchronization of cortical high frequency oscillations and integration of multiple whisker responses.

► Slow wave component responses (SW) to multivibrissa stimulation sum sublinearly. ► Fast oscillation responses (>200 Hz, FO) to multivibrissa stimulation sum supralinearly. ► Gap junction blocker eliminates supralinear response of FO and does not change SW.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 85, Issue 6, 15 July 2011, Pages 424-428
نویسندگان
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