کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262379 1613796 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportCathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research reportCathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells
چکیده انگلیسی


- Curcumin treatment increased cathepsin L activity in glioma cells.
- Cathepsin L knockdown could enhance the sensitivity of glioma cells to curcumin.
- Inhibition of cathepsin L may be exploited in adjuvant clinical glioma therapy.

Curcumin can be used to prevent and treat cancer. However, its exact underlying molecular mechanisms remain poorly understood. Cathepsin L, a lysosomal cysteine protease, is overexpressed in several cancer types. This study aimed to determine the role of cathepsin L in curcumin-mediated inhibition of growth, migration, and invasion of glioma cells. Results revealed that the activity of cathepsin L was enhanced in curcumin-treated glioma cells. Cathepsin L knockdown induced by RNA interference significantly promoted curcumin-induced cytotoxicity, apoptosis, and cell cycle arrest. The knockdown also inhibited the migration and invasion of glioma cells. Our results suggested that the inhibition of cathepsin L can enhance the sensitivity of glioma cells to curcumin. Therefore, cathepsin L may be a new target to enhance the efficacy of curcumin against cancers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1646, 1 September 2016, Pages 580-588
نویسندگان
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