کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262467 1613798 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportSleep restriction reduces the survival time and aggravates the neurological dysfunction and memory impairments in an animal model of cerebral hypoperfusion
ترجمه فارسی عنوان
محدودیت های خواب رفتن باعث کاهش زمان بقا می شود و اختلالات عصبی و اختلالات حافظه را در یک مدل حیوانی از هیپرفرفی مغزی
کلمات کلیدی
محدودیت خواب، هیپرفرفی مغزی، عملکرد مغز و اعصاب، حافظه، میزان مرگ و میر،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Sleep restriction reduced the survival time after global cerebral hypoperfusion.
- Sleep restriction was associated with a higher frequency of neurological dysfunction.
- Sleep restriction was associated with a higher frequency of memory impairments.

Cerebral blood flow is associated with the cerebrovascular prognosis. Sleep restriction (SR) may be a limiting factor of the prognosis after a cerebrovascular event, impairing the neurological recovery. We aimed to investigate the effects of SR on mortality rate and on behavioral and histological parameters of animals submitted to permanent cerebral hypoperfusion. Sixty male Wistar rats were distributed in 4 groups, according to the protocol of common carotid artery occlusion (CCAO) and SR: nSR+nCCAO, SR+nCCAO, nSR+CCAO, and SR+CCAO. The groups SR+nCCAO and SR+CCAO were submitted to SR during 10 days. The cerebral hypoperfusion was induced by the permanent CCAO. Neurological function and memory were assessed over 14 days of cerebral hypoperfusion. Analysis of neuropathological alterations were performed in the CA1 region of hippocampus. The mortality rate was 40% in the nSR+CCAO and SR+CCAO groups. SR significantly reduced the survival time of animals submitted to CCAO. After 7 and 14 days of cerebral hypoperfusion, 11% and 33% of the nSR+CCAO and SR+CCAO animals showed severe neurological dysfunction, respectively. A significant association between a high frequency of memory impairments with the group SR+CCAO was observed. The neuropathological alterations in CA1 region of hippocampus were similar among the groups. SR potentiates the negative effects of cerebral hypoperfusion conditions, suggesting that SR could be a factor associated with a worse prognosis after a cerebrovascular event.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1644, 1 August 2016, Pages 213-221
نویسندگان
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