کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262686 1292374 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewFronto-striatal circuits in response-inhibition: Relevance to addiction
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
ReviewFronto-striatal circuits in response-inhibition: Relevance to addiction
چکیده انگلیسی


- Human and animal response-inhibition can inform substance dependence theorizing.
- Response-inhibition difficulties contribute to impulsivity and compulsivity.
- Response-inhibition can serve as a useful measure of fronto-striatal integrity.

Disruptions to inhibitory control are believed to contribute to multiple aspects of drug abuse, from preexisting vulnerability in at-risk individuals, through escalation to dependence, to promotion of relapse in chronic users. Paradigms investigating the suppression of actions have been investigated in animal and human research on drug addiction. Rodent research has focused largely on impulsive behaviors, often gauged by premature responding, as a viable model highlighting the relevant role of dopamine and other neurotransmitters primarily in the striatum. Human research on action inhibition in stimulant dependence has highlighted impaired performance and largely prefrontal cortical abnormalities as part of a broader pattern of cognitive abnormalities. Animal and human research implicate inhibitory difficulties mediated by fronto-striatal circuitry both preceding and as a result of excessive stimulus use. In this regard, response-inhibition has proven a useful cognitive function to gauge the integrity of fronto-striatal systems and their role in contributing to impulsive and compulsive features of drug dependence.This article is part of a Special Issue entitled SI:Addiction circuits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1628, Part A, 2 December 2015, Pages 117-129
نویسندگان
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