کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262882 1613815 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportElectrolytic lesions of the bilateral ventrolateral orbital cortex inhibit methamphetamine-associated contextual memory formation in rats
ترجمه فارسی عنوان
گزارش تحقیقات ضایعات الکترولیتی قشر مغزی ونتروکراتیک دوطرفه، تشکیل حافظه متسئم متامفتامین در موش صحرایی را مهار می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- VLO lesions could delay the CPP acquisition and extinction without affecting its expression level.
- VLO lesions do not have obvious influence on CPP reinstatement.
- VLO could facilitate cue-associated contextual memory formation in rats.
- VLO may not critically involve in memory storage and retrieval.

The memories that are formed between rewarding and drug-associated contextual cues have been suggested to contribute to drug addiction relapse. Recent evidence has indicated that the ventrolateral orbital cortex (VLO) plays important roles in reward-based learning and reversal learning. However, whether the VLO is required for methamphetamine-induced contextual memory formation is not well understood. In the present study, a three-phase methamphetamine-induced conditioned place preference (CPP) model was used to investigate the effects of VLO lesions on the formation of drug-associated contextual memories in rats. We found that the VLO lesions themselves elicited no observable effects on place preferences. However, the VLO lesions delayed the acquisition and extinction phases of CPP without affecting the expression level. Furthermore, the VLO lesions did not have an obvious influence on CPP reinstatement. These results indicate that electrolytic lesions of the bilateral ventrolateral orbital cortex can inhibit the formation of methamphetamine-induced contextual memories in rats. Moreover, VLO may not be critically involved in memory storage and retrieval.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1624, 22 October 2015, Pages 214-221
نویسندگان
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