کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6263056 | 1613821 | 2015 | 13 صفحه PDF | دانلود رایگان |
- The brain network underlying recollection was examined across the lifespan.
- Hippocampal activity was related to unsuccessful recollection in older adults.
- Age effects on the recollection brain network follow different patterns.
- The recollection brain network showed no modifications at middle age.
We investigated neurofunctional changes associated with source memory decline across the adult life span using functional magnetic resonance imaging (fMRI). Young, middle-aged and old adults carried out a natural/artificial judgment of images of common objects that were randomly presented in one of the quadrants of the screen. At retrieval, the images were displayed at the center of the screen and the participants judged whether each image was new or old and, if old, they indicated in which quadrant of the screen the image had originally been presented. Comparing the items associated with correct versus incorrect source judgments revealed that no regions showed greater activity in young adults than in middle-aged adults; however, in young and middle-aged adults the activity in the left hippocampus and left anterior temporal cortex was of greater magnitude than in the older adults. Several regions also exhibited greater activity in young adults than in old adults. These results suggest that in middle age the recollection neural network, assessable by fMRI, is still preserved.
Journal: Brain Research - Volume 1618, 27 August 2015, Pages 168-180