کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6263563 1613902 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportSerum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis
ترجمه فارسی عنوان
گزارش تحقیقاتی سرم نیکوتین آمید سطوح آدنین دینوکلئوتید را از طریق دوره بیماری در بیماری مولتیپل اسکلروزیس بررسی می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Serum NAD+ levels were significantly lower in patients with MS compared to controls (p=0.0012).
- Within the MS sub-groups NAD+ levels were higher in RRMS (p=0.001) compared to PPMS (p=0.003) and SPMS (p=0.005).
- Higher levels of NADH (p=0.002) and a lower NAD+/NADH ratio (p=0.009) were observed in MS patients compared to controls.
- Serum NAD+ and NADH levels are may be associated with disease progression in MS.

The levels of the essential pyridine nucleotide, NAD+ and its reduced form NADH have not been documented in MS patients. We aimed to investigate NAD+ and NADH levels in serum in patients with different disease stages and forms of MS. NAD+ and NADH levels were measured in the serum from 209 patients with relapsing remitting MS (RRMS), 136 with secondary progressive MS (SPMS), 51 with primary progressive MS (PPMS), and 99 healthy controls. All patients were in a clinically stable phase. Serum NAD+ levels declined by at least 50% in patients with MS compared to controls (17.9±3.2 μg/ml; p=0.0012). Within the MS sub-groups NAD+ levels were higher in RRMS (9.9±2.9 μg/ml; p=0.001) compared to PPMS (6.3±2.1 μg/ml; p=0.003) and SPMS (7.8±2.0 μg/ml; p=0.005). A two-fold increase in NADH levels (p=0.002) and at least three-fold reduction in the NAD+/NADH ratio (p=0.009) were observed in MS patients compared to controls. Serum NAD+ and NADH levels are may be associated with disease progression in MS. Given the importance of NAD+ in the maintenance of normal cellular function, it is likely that this molecule is of therapeutic relevance in MS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1537, 6 November 2013, Pages 267-272
نویسندگان
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