Modulation of methamphetamine-induced nitric oxide production by neuropeptide Y in the murine striatum

► We investigated the role of neuropeptide Y on the methamphetamine-induced production of striatal nitric oxide. ► Neuropeptide Y receptor agonists (Y1 and Y2) attenuate nitric oxide production stimulated by methamphetamine. ► Neuropeptide Y2 receptor agonist inhibits the co-expression of cyclic GMP and activated caspase-3 in some striatal neurons. ► Preproneuropeptide Y mRNA is increased by methamphetamine suggesting increased utilization of the peptide.