Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments

► Dopamine induces endosomal translocation of APP in Neuro2A neuroblastoma cells. ► Dopamine promotes amyloidogenic processing of APP within endosomes. ► Amyloidogenic processing of APP eventually causes lysosome leakage and apoptosis. ► Pepstatin A and chloroquine inhibit dopamine-induced processing of APP. ► Pepstatin A and chloroquine prevent apoptosis induced by dopamine.