کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6264778 | 1614034 | 2011 | 8 صفحه PDF | دانلود رایگان |

Centrally acting cannabinoids are well known for their ability to impair functions associated with both learning and memory but appreciation of the physiological mechanisms underlying these actions, particularly those that persist, remains incomplete. Our earlier studies have shown that song stereotypy is persistently reduced in male zebra finches that have been developmentally exposed to cannabinoids. In the present work, we examined the extent to which changes in neuronal morphology (dendritic spine densities and soma size) within brain regions associated with zebra finch vocal learning are affected by late-postnatal cannabinoid agonist exposure. We found that daily treatment with the cannabinoid agonist WIN55212-2 (WIN, 1Â mg/kg IM) is associated with 27% and 31% elevations in dendritic spine densities in the song regions Area X and HVC, respectively. We also found an overall increase in cell diameter within HVC. Changes in dendritic spine densities were only produced following developmental exposure; treatments given to adults that had completed vocal learning were not effective. These findings have important implications for understanding how repeated cannabinoid exposure can produce significant, lasting alteration of brain morphology, which may contribute to altered development and behavior.
⺠Zebra finches were treated developmentally with cannabinoids. ⺠Densities of dendritic spines and cell diameters were measured in song regions. ⺠Increased dendritic spine densities were produced in HVC and Area X and cell diameters were increased in HVC. ⺠Differences followed sensorimotor, but not adult treatments. ⺠Changes in HVC and Area X are associated with cannabinoid-altered vocal development.
Journal: Brain Research - Volume 1405, 8 August 2011, Pages 23-30