Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats

► Oral administration of Rb1 improves spatial cognitive function of rats. ► Rb1 increases cell survival in dentate gyrus and CA3 subregion of the hippocampus. ► Rb1 has no significant influence on cell proliferation in the rat hippocampus.