کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6265754 | 1614198 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research ReportStereo-selective neuroprotection against stroke with vitamin A derivatives Research ReportStereo-selective neuroprotection against stroke with vitamin A derivatives](/preview/png/6265754.png)
In this study we evaluated the neuroprotective potential of vitamin A (all-trans retinol), and its geometric isomers, all-trans retinoic acid and 9-cis retinoic acid, in a focal model of ischemia. A 60Â minute middle cerebral artery occlusion in C57 mice resulted in over 50% hemispheric infarction. Vitamin A (retinol) and its derivatives were administered as two i.p. injections immediately prior to and following ischemia. A reduction in infarct volume was observed with all-trans retinol, in a dose-dependent manner: maximum protection was observed with a 10Â mg/kg dose. A similar protective profile was observed with all-trans retinol, but not the stereo-isomer 9-cis retinoic acid. Administration of the derivatives 1Â h following ischemia did not produce significant protection. Taken together these data suggest a possible use of vitamin A derivatives as an acute neuroprotective strategy for stroke.
Journal: Brain Research - Volume 1241, 19 November 2008, Pages 188-192