A novel experimental in vivo model of cerebral immunomodulation induced by inactivated Staphylococcus epidermidis

► Model for the initiation, maintenance and modulation of acute neuroinflammation due to direct exposure of bacterial antigens. ► Localized and dose dependent influx of systemic immunocompetent cells into the brain with opening of the blood-brain barrier. ► Well-ordered and reproducible time course of initiated cerebral inflammatory response. ► No collateral tissue damage. ► Simple, easy reproducible experimental design, well tolerated by experimental animals.