Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

► Mouse behavior related to emotionality is multimodal and varies over time. ► Tools to integrate behavioral parameters from complementary tests are needed. ► z-normalization yields robust behavioral measures across complementary tests in mice. ► Emotionality z-scores increase the comprehensiveness of behavioral testing. ► Emotionality z-scores highlight subtle baseline emotionality sex differences.