Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro

▶ Retinoic acid and its stable analogue EC23 enhance the neural development in vitro. ▶ Synthetic retinoid EC23 is a potent regulator of neuroprogenitor cell maturation. ▶ Synthetic retinoid EC23 enhances the formation of motor neurons by human ES cells. ▶ Retinoid supplements improve reliability and consistency of neural differentiation.