کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6270649 | 1614737 | 2016 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Absence of neurogenic response following robust predator-induced stress response
ترجمه فارسی عنوان
عدم پاسخ عصبی ناشی از واکنش شدید مقاوم به شکارچی استرس
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کلمات کلیدی
GRsPBSTBSTMTSGZNDSSSRIsGCLpost-traumatic stress disorder - اختلال استرس پس از ضربهPTSD - اختلال استرسی پس از ضایعه روانیImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیBrdU - بروموداکسی اوریدینanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancePredator stress - تنش شکارچیCognitive behavioral therapy - درمان رفتاری شناختیCBT - رفتار درمانی شناختی normal donkey serum - سرم عسل طبیعیgranular cell layer - لایه سلولی گرانولPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریsubgranular zone - منطقه غده گرانولیselective serotonin re-uptake inhibitors - مهار کننده های انتخاب مجدد جذب سروتونینAdult hippocampal neurogenesis - نوروژنز هیپوکامپ بزرگسالانCORT - کورتCorticosterone - کورتیکوسترونglucocorticoid receptors - گیرنده های گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Traumatic events contribute to a variety of neuropsychiatric disorders including post-traumatic stress disorder (PTSD). Identifying the neural mechanisms that affect the stress response may improve treatment for stress-related disorders. Neurogenesis, the production of neurons, occurs within the adult brain and disturbances in neurogenesis in the subgranular zone (SGZ) of the hippocampus have been linked to mood and anxiety disorders. Chronic stress models have mainly suggested correlations with stress reducing adult SGZ neurogenesis, whereas acute stress models and those with a naturalistic component that are also associated with long-lasting behavioral changes have produced inconsistent results. Therefore, the goal of the current study was to examine the effects of acute predator stress on adult neurogenesis. Predator stress involved a single 10-min unprotected rat to cat exposure that has previously been shown to produce contextual fear, hyperarousal, and anxiety-like behavior lasting at least 3Â weeks. As expected, predator stress produced a stress response as detected by elevated corticosterone (CORT) levels immediately after stress. Despite this robust stress response, there was no significant difference between stressed and handled control rats in the number of proliferating or surviving cells as assessed by a 5-bromo-2â²-deoxyuridine-immunoreactive (BrdU-IR) labeling 2Â h or 4Â weeks post-stress throughout the rostro-caudal axis of the SGZ, respectively. Additionally, 90% of 4-week-old BrdU-IR cells in both conditions expressed NeuN, suggesting no change in cell fate with stress exposure. Overall, these data give caution to the notion that acute predator stress can alter the production or survival of adult-generated cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 339, 17 December 2016, Pages 276-286
Journal: Neuroscience - Volume 339, 17 December 2016, Pages 276-286
نویسندگان
Catherine Lau, Mark Hebert, Marc A. Vani, Sue Walling, Shawn Hayley, Diane C. Lagace, Jacqueline Blundell,