کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6270806 1614744 2016 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Paternal age and diet: The contributions of a father's experience to susceptibility for post-concussion symptomology
ترجمه فارسی عنوان
سن پدر و رژیم غذایی: مشارکت یک تجربه پدر و مادر در مورد حساسیت به علائم پس از سکته مغزی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Individual heterogeneity in concussion susceptibility may be linked to pre-injury factors, including paternal influence.
- Advanced paternal age and consumption of a High-Fat Diet prior to conception altered baseline and post-injury behavior.
- Paternal experiences modified expression of multiple genes in the hippocampus, prefrontal cortex, & nucleus accumbens.
- The experiences of fathers prior to conception play a role in offspring health and warrant further examination.

In an attempt to improve current understanding of risk factors that influence individual susceptibility to poor outcomes following mild traumatic brain injury (mTBI) or concussion, this project investigated whether modifications to paternal experiences (Advanced Age (AA) or High-Fat Diet (HFD)) affected offspring susceptibility to behavioral symptomology and changes in gene expression following pediatric concussion in a rodent model. The study demonstrated that paternal treatment prior to conception altered behavioral outcomes and molecular characterization of offspring. Offspring of AA fathers demonstrated abnormal behavioral performance when compared to offspring of control fathers. Similarly, paternal HFD altered pathophysiological outcomes for offspring, contributing to the heterogeneity in post-concussion syndrome. Additionally, this study provided insight into the mechanisms that mediate non-genetic paternal inheritance. Paternal treatment and the mTBI significantly influenced expression of a majority of the genes under examination in the prefrontal cortex, hippocampus, and nucleus accumbens, with changes being dependent upon sex and the brain region examined. These epigenetic changes may have contributed to the differences in offspring susceptibility to concussion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 332, 22 September 2016, Pages 61-75
نویسندگان
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