کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6271134 1614748 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin-1 receptor is a target for adjunctive control of diazepam-refractory status epilepticus in mice
ترجمه فارسی عنوان
گیرنده اینترلوکین-1 یک هدف برای کنترل افزاینده صرع اپیتلیوم وضعیت مقاوم در برابر دیازپام در موش است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Diazepam failed to terminate prolonged SE when hippocampal level of IL-1β increased.
- Prolonged SE was not diazepam-refractory in IL-1R1 knock-out mice.
- Administration of IL-1RA combined with diazepam terminated established prolonged SE.
- Administration of IL-1β weakened the efficacy of diazepam on non-refractory SE.

Proinflammatory cytokine interleukin-1 beta (IL-1β) may accumulate in the brain during status epilepticus, but whether it contributes to the progressive refractoriness of SE remains unclear. By using a kainic acid-induced SE mice model, we tested whether pharmacological blockade or knock-out of interleukin-1 receptor type 1 (IL-1R1) could influence the diazepam-refractory phenomenon of prolonged SE. We confirmed diazepam failed to terminate prolonged SE (allowed to continue for 40 min before diazepam administration). The expression level of IL-1β in the hippocampus during prolonged SE was significantly higher than that of baseline. Interestingly, prolonged SE was not diazepam-refractory in IL-1R1 knock-out mice. Moreover, administration of interleukin-1 receptor antagonist (IL-1RA) combined with diazepam terminated established prolonged SE, while IL-1RA alone is not capable to terminate prolonged SE. On the contrary, administration of recombinant human IL-1β weakens the efficacy of diazepam by prolonging its latency to terminate non-prolonged SE. Thus, the present study provides direct evidence that accumulated IL-1β contributed to the diazepam refractoriness of prolonged SE, and suggests that interleukin-1 receptor is a target for adjunctive control of diazepam-refractory SE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 328, 22 July 2016, Pages 22-29
نویسندگان
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