کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6271936 1614768 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination
چکیده انگلیسی
Receptor protein tyrosine phosphatases (RPTPs) are extensively expressed in the central nervous system (CNS), and have distinct spatial and temporal patterns in different cell types during development. Previous studies have demonstrated possible roles for RPTPs in axon outgrowth, guidance, and synaptogenesis. In the present study, our results revealed that protein tyrosine phosphatase, receptor type D (PTPRD) was initially expressed in mature neurons in embryonic CNS, and later in oligodendroglial cells at postnatal stages when oligodendrocytes undergo active axonal myelination process. In PTPRD mutants, oligodendrocyte differentiation was normal and a transient myelination delay occurred at early postnatal stages, indicating the contribution of PTPRD to the initiation of axonal myelination. Our results also showed that the remyelination process was not affected in the absence of PTPRD function after a cuprizone-induced demyelination in adult animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 308, 12 November 2015, Pages 106-114
نویسندگان
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