Keywords: Cuprizone; Behavior; Demyelination; Dopaminergic activity;
مقالات ISI (ترجمه نشده)
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Keywords: Flavanone derivative; Cuprizone; Schizophrenia; Demyelination; Oligodendrocytes; Neuroinflammation;
Keywords: CON; control; CSE; cuprizone short-term exposure; DSM; Diagnostic and Statistical Manual of Mental Disorders; ED; exposure day; FST; forced swim test; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium-binding adaptor molecule 1; IL-6; interleuk
Keywords: Axonal damage; APP; Experimental autoimmune encephalomyelitis; Cuprizone; Lysolecithin;
Keywords: Triiodothyronine; Cuprizone; Remyelination; Oligodendrocyte progenitor cells
Keywords: Cuprizone (CPZ); Expression microarray; Myelination; Synaptic transmission; KLOTHO; Glial cell development; ACHE; acetylcholinesterase; CCL2; chemokine (C-C motif) ligand 2; CD68; cluster of differentiation 68; CPZ; cuprizone; CT; threshold cycle; CNPas
Keywords: AAV; adeno-associated virus; BDNF; brain-derived neurotrophic factor; CNP; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNS; central nervous system; CNTF; ciliary neurotrophic factor; CNTFRα; ciliary neurotrophic factor receptor alpha; Cop-1; copa
Keywords: Eicosapentaenoic acid; Cuprizone; Myelin; Rat
Keywords: Magnetic resonance imaging; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Theiler's murine encephalomyelitis virus; Lysolecithin; Cuprizone
Keywords: Cuprizone; Oligodendrocyte; Myelin; Metabolic stress; Neuroinflammation; Demyelination; Remyelination; Multiple sclerosis; Epilepsy; Schizophrenia;
Quantitative determination of cyclic phosphatidic acid and its carba analog in mouse organs and plasma using LC-MS/MS
Keywords: 2ccPA; 2-carba-cyclic phosphatidic acid; ATX; autotaxin; BSA; bovine serum albumin; CID; collision-induced dissociation; CNS; central nervous system; cPA; cyclic phosphatidic acid; CV; coefficient of variation; EDTA-Na2; ethylenediaminetetraacetic acid di
Quantitative analysis of lipid debris accumulation caused by cuprizone induced myelin degradation in different CNS areas
Keywords: BODIPY; boron-dipyrromethene; CA; anterior commissure; CARS; coherent anti-Stokes Raman scattering; CB; cerebellum; CC; corpus callosum; CNS; central nervous system; FM; forceps minor of corpus callosum; GM; grey matter; MAG; myelin-associated glycoprotei
1,25-Dihydroxyvitamin-D3 induces brain proteomic changes in cuprizone mice during remyelination involving calcium proteins
Keywords: Cuprizone; Remyelination; Multiple sclerosis; 1,25-Dihydroxyvitamin-D3; TMT-Labeling; Quantitative proteomics; Immunohistochemistry; Calretinin; S10A5; Secretagogin; 1,25-Dihydroxyvitamin D3 (PubChem CID 5280453); Biscyclohexanone oxaldihydrazone (cuprizo
Low, but not high, dose triptolide controls neuroinflammation and improves behavioral deficits in toxic model of multiple sclerosis by dampening of NF-κB activation and acceleration of intrinsic myelin repair
Keywords: Apoptosis; Cuprizone; Demyelination; Multiple sclerosis; Neuroinflammation; Triptolide;
The antibody rHIgM22 facilitates hippocampal remyelination and ameliorates memory deficits in the cuprizone mouse model of demyelination
Keywords: rHIgM22; Remyelination; Cuprizone; Hippocampus; Memory; Multiple sclerosis;
Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination
Keywords: CPZ; copper chelator cuprizone; DG; dentate gyrus; GCL; granular cell layer; LDL-R; low-density lipoprotein receptor; MTs; metallothioneins; OLGs; oligodendrocytes; OPCs; oligodendrocyte progenitor cells; PBS; phosphate-buffered saline; PLA; proximity lig
Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone model
Keywords: Multiple sclerosis; Cuprizone; Demyelination; Remyelination; Vitamin D; Axonal damage;
Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation
Keywords: Cuprizone; Demyelination; Multiple sclerosis; Linagliptin; SIRT1; AMPK;
Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice
Keywords: Cuprizone; TRPA1 receptor; Demyelination; Magnetic resonance imaging; Electron microscopy; Open field test; TRPA1; transient receptor potential ankyrin 1; LFB; Luxol Fast Blue; CV; Cresyl Violet; DPA; dynamic plantar aesthesiometer; IHC; immunohistochemis
Postnatal Sonic hedgehog (Shh) responsive cells give rise to oligodendrocyte lineage cells during myelination and in adulthood contribute to remyelination
Keywords: Cuprizone; Demyelination; Remyelination; Oligodendrogenesis; Oligodendrocyte progenitor; Sonic hedgehog; Myelination; Gli1; Oligodendrocyte lineage; Genetic fate labeling;
Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR-136-5p and long non-coding RNA HOTAIR in cuprizone-induced demyelination
Keywords: Cuprizone; bis-(cyclohexanone)-oxaldihydrazone; ceRNA; competing endogenous RNA; LFB; luxol fast blue; LncRNA; long non-coding RNA; MBP; myelin basic protein; MOG; myelin oligodendrocyte glycoprotein; MS; multiple sclerosis; NF-κB; nuclear factor kappa B
Probenecid-treatment reduces demyelination induced by cuprizone feeding
Keywords: Demyelinating diseases; Cuprizone; Pannexins; Probenecid;
Humanin affects object recognition and gliosis in short-term cuprizone-treated mice
Keywords: Humanin; Cuprizone; Neuroinflammation; Amnesia;
Research reportIcariin enhances remyelination process after acute demyelination induced by cuprizone exposure
Keywords: Myelin; Oligodendrogenesis; Cuprizone; Demyelination; Multiple sclerosis;
Research PaperiPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response
Keywords: CNS; central nervous system; CM; conditioned media; cup; cuprizone; ESCs; embryonic stem cells; iPSCs; induced pluripotent stem cells; MS; multiple sclerosis; NPCs; neural progenitor cells; OLs; oligodendrocytes; OPCs; oligodendrocyte progenitor cells; PP
rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination
Keywords: rHIgM22; Remyelination; Demyelination; Cuprizone; Corpus callosum; Oligodendrocytes; Multiple sclerosis;
Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination
Keywords: DKO; Gpr37/Gpr37L1 double knockout; EDTA; ethylenediaminetetraacetic acid; ERK; extracellular signal-regulated kinase; GPCRs; G protein-coupled receptors; Gpr37; Gpr37 knockout; GPR37L1; G protein-coupled receptor 37 like-1; Gpr37L1; Gpr37L1 knockout; GST
A Minimally-invasive Blood-derived Biomarker of Oligodendrocyte Cell-loss in Multiple Sclerosis
Keywords: Relapsing-remitting multiple sclerosis; Oligodendrocyte; Cuprizone; Human patients; Circulating free DNA; Biomarker discovery
Phosphodiesterase-5 inhibition promotes remyelination by MCP-1/CCR-2 and MMP-9 regulation in a cuprizone-induced demyelination model
Keywords: Sildenafil; Neuroinflammation; Demyelination; Oligodendrocyte; Cuprizone
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system
Keywords: Tβ4; thymosin beta 4; MS; multiple sclerosis; EAE; experimental autoimmune encephalomyelitis; OPC; oligodendrocyte progenitor cell; EGFR; epidermal growth factor receptor; pEGFR; phosphorylated EGFR; APP; amyloid beta/A4 precursor protein; BrdU; bromodeo
Fingolimod does not enhance cerebellar remyelination in the cuprizone model
Keywords: S1P; sphingosine 1-phosphate; Wr; weeks of recovery; β-APP; amyloid β precursor protein; IHC; immunohistochemistry; PL; Purkinje layer; GL; granule layer; FTY720; Fingolimod; Cuprizone; Cerebellum; Demyelination; Remyelination;
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination
Keywords: ISH; in situ hybridization; OPCs; oligodendrocyte progenitor cells; PFA; paraformaldehyde; PTKs; protein tyrosine kinases; PTPRD; protein tyrosine phosphatase, receptor type D; PTPRS; protein tyrosine phosphatase, receptor type S; PTPs; protein tyrosine p
Immunopharmacology and inflammationQuetiapine mitigates the neuroinflammation and oligodendrocyte loss in the brain of C57BL/6 mouse following cuprizone exposure for one week
Keywords: Antipsychotic; Cuprizone; Mice; Neuroinflammation; Oligodendrocytes; Schizophrenia;
Beneficial effects of bone marrow-derived mesenchymal stem cell transplantation in a non-immune model of demyelination
Keywords: Bone marrow-derived mesenchymal stem cells; Intravenous; Transplantation; Cuprizone; Demyelination;
Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system
Keywords: RFP; red fluorescent protein; MSC; MS; Cuprizone; Intraventricular; Corpus callosum;
Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model
Keywords: Sildenafil; Neuroinflammation; Demyelination; AMPK; NFkB; Cuprizone
The cuprizone-induced changes in 1H-MRS metabolites and oxidative parameters in C57BL/6 mouse brain: Effects of quetiapine
Keywords: Mitochondrial dysfunction; Oxidative stress; Quetiapine; Cuprizone; MRS; Mouse;
Cuprizone decreases intermediate and late-stage progenitor cells in hippocampal neurogenesis of rats in a framework of 28-day oral dose toxicity study
Keywords: ARC; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived neurotrophic factor; BLBP; brain lipid binding protein; CALB1; calbindin-D-28K; CALB2; calbindin-D-29K; CHRNA7; cholinergic receptor, nicotinic, alpha polypeptide 7; CNS; central
Concurrent changes in 1H MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone: Possible implications for schizophrenia
Keywords: Cuprizone; Mouse; MRS; Brain metabolites; Schizophrenia
Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model
Keywords: Cuprizone; Copper chelation; Mitochondrial toxicity; Demyelination; Selective vulnerability; Multiple sclerosis;
FGF2 and FGFR1 signaling regulate functional recovery following cuprizone demyelination
Keywords: Cup; cuprizone; FGF2; fibroblast growth factor 2 ligand; Fgf2; gene encoding murine fibroblast growth factor 2; FGFR1; fibroblast growth factor receptor 1; Fgfr1; gene encoding murine fibroblast growth factor receptor 1; fl; floxed gene; MOG; myelin oligo
Oligodendrogenesis from neural stem cells: Perspectives for remyelinating strategies
Keywords: MS; multiple sclerosis; NPCs; neural precursor cells; CNS; central nervous system; PDGFRα; platelet-derived growth factor receptor alpha; OPCs; oligodendrocyte precursor cells; PNS; peripheral nervous system; NSCs; neural stem cells; SVZ; subventricular
Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BSA; bovine serum albumin; CC; corpus callosum; CNS; central nervous system; EAAT; excitatory amino acid transporter; EAE; experimental allergic encephalomyelitis; ECL; enhanced chemiluminescenc
Alterations of brain eicosanoid synthetic pathway in multiple sclerosis and in animal models of demyelination: Role of cyclooxygenase-2
Keywords: Arachidonic acid; Cyclooxigenases; Multiple sclerosis; NSAID; Cuprizone; EAE; Theiler's virus
Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology
Keywords: multiple sclerosis; experimental autoimmune encephalomyelitis; cuprizone; NF-κB; demyelination; Th17
Rolipram promotes remyelination possibly via MEK-ERK signal pathway in cuprizone-induced demyelination mouse
Keywords: Rolipram; PDE4 inhibitor; Demyelination; Remyelination; Oligodendrocyte precursor cell; Cuprizone; MAPK;
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperMagnetic resonance imaging and histological evidence for the blockade of cuprizone-induced demyelination in C57BL/6 mice
Keywords: cuprizone; demyelination; schizophrenia; mouse; MRI; quetiapine; CPZ; cuprizone; DTI; diffusion tensor imaging; FA; fractional anisotropy; FOV; Field of View; LFB; Luxol Fast Blue; MBP; Myelin Basic Protein; MRI; magnetic resonance imaging; MS; multiple s
The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain
Keywords: T2* decay; R2* relaxation; Phase image; Resonance frequency image; Demyelination; Cuprizone; Formalin fixation;
Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination
Keywords: Quetiapine; Schizophrenia; Oligodendrocyte; Remyelination; Cuprizone; Olig2;
Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?
Keywords: Microglia; Cuprizone; Remyelination; Phagocytosis;