کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271943 | 1614776 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex
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کلمات کلیدی
resting membrane potentialsRMPSeIPSCsN-methyl-d-aspartic acidsIPSCsminiature IPSCsmIPSCsDNQXPTXAP-5PFCMPFCHEPESPPFEGTAPHENMDATTXaCSF4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acid6,7-dinitroquinoxaline-2,3-dione - 6،7-dinitroquinoxaline-2،3-dioneAPs - AP هاethylene glycol tetraacetic acid - اتیلن گلیکول تتراستیک اسیدtetrodotoxin - تترو دوتوکسین paired-pulse facilitation - تسکین زوایای پالسیfast-spiking - سریع اسپایکینگphenylephrine - فنیل آفرینprefrontal cortex - قشر prefrontalmedial prefrontal cortex - قشر غده پروسترولartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیaction potentials - پتانسیل های عملیPicrotoxin - پیکروتوکسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex](/preview/png/6271943.png)
چکیده انگلیسی
Whereas activation of α1-adrenoceptors (α1-ARs) modulates glutamatergic transmission, the roles of α1-ARs in GABAergic transmission in the medial prefrontal cortex (mPFC) are elusive. Here, we examined the effects of the α1-AR agonist phenylephrine (Phe) on GABAergic transmission onto pyramidal neurons in the deep layers of the mPFC. We found that bath application of Phe dose-dependently increased the amplitude of evoked IPSCs (eIPSCs). Phe increased the frequency but not the amplitude of miniature IPSCs (mIPSCs). Ca2+ influx through T-type voltage-gated calcium channels is required for Phe-induced increases in GABA release. Phe increases GABA release probability and the number of releasable vesicles. Phe depolarizes the fast-spiking (FS) interneurons without effects on the firing rate of action potentials (APs) of interneurons. Phe-induced depolarization is independent of extracellular Na+, Ca2+ and T-type calcium channels, but requires inward rectifier K+ channels (Kirs). The present study demonstrates that Phe enhances GABAergic transmission onto mPFC pyramidal neurons through inhibiting interneurons Kirs, which further depolarizes interneurons leading to increase in Ca2+ influx via T-type calcium channels. Our results may provide a cellular and molecular mechanism that helps explain α1-AR-induced PFC dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 300, 6 August 2015, Pages 63-74
Journal: Neuroscience - Volume 300, 6 August 2015, Pages 63-74
نویسندگان
F. Luo, H. Tang, Z.-y. Cheng,