Keywords: پیکروتوکسین; ACSF; artificial cerebrospinal fluid; CCh; carbachol; CPP; 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonate; EC; entorhinal cortex; GABAA; γ-aminobutyric acid type A receptor; LTP; long-term potentiation; MVSDs; moving standard deviations; NBQX; 2,3-dihy
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Keywords: پیکروتوکسین; AD; Alzheimer's disease; ACSF; artificial cerebro-spinal fluid; CBF; cerebral blood flow; fEPSP; field excitatory postsynaptic potential; GCL; granule cell layer; GLUTs; glucose transporters; 4-HNE; 4-hydroxynonenal; LTP; long-term potentiation; LTD; long
Keywords: پیکروتوکسین; Clonic-tonic seizures; Intravenous anesthetics; Midazolam; Picrotoxin; Propofol;
Keywords: پیکروتوکسین; Epilepsy; Excitatory postsynaptic current; Neurotransmission; Phenytoin; Picrotoxin; Voltage-gated Na+ channelAP, action potential; AED, anti-epileptic drug; [Ca2+]i, intracellular Ca2+ concentrations; EPSC, excitatory postsynaptic current; Nav, voltage-g
Keywords: پیکروتوکسین; Fear extinction; Retrieval; C57BL/6J; 129S1/SvImJ; Picrotoxin; Fluoxetine; Infralimbic cortex; Prelimbic cortex
Keywords: پیکروتوکسین; Electroretinogram; Distal retina; Frog; GABA; Picrotoxin; Proximal retina
Keywords: پیکروتوکسین; Midazolam; Pentylenetetrazol; Picrotoxin; Kainic acid; Seizures; Intratracheal administration; Pulmonary drug delivery;
Keywords: پیکروتوکسین; Myrothamnus moschatus; Essential oil; Convulsions; Pentylenetetrazole; Picrotoxin
Keywords: پیکروتوکسین; Picrotoxin (PubChem CID: 442292)Drosophila melanogaster; Locomotor activity; Seizures; GABAA receptors; Rdl; Picrotoxin; Methods
β-adrenergic receptors reduce the threshold for induction and stabilization of LTP and enhance its magnitude via multiple mechanisms in the ventral but not the dorsal hippocampus
Keywords: پیکروتوکسین; Hippocampus; Septotemporal; Dorsoventral; Beta adrenergic receptor; Noradrenaline; Long-term potentiation; DH; dorsal hippocampus; β-AR; β adrenergic receptor; HFS; high-frequency stimulation; ISO; isoproterenol; PPF; paired-pulse facilitation; PRO; pro
Anticonvulsant effect of the hydroethanolic leaf extract of Psydrax subcordata (DC.) Bridson in murine models
Keywords: پیکروتوکسین; 4-AP; 4-aminopyridine; AED; antiepileptic drug; ANOVA; analysis of variance; CNS; central nervous system; COX; cyclooxygenase; DZ; diazepam; PSE; Psydrax subcordata extract; FMZ; flumazenil; GABA; gamma-amino butyric acid; LMICs; low- and middle- income c
Effects of picrotoxin on zebrafish larvae behaviors: A comparison study with PTZ
Keywords: پیکروتوکسین; Zebrafish; Picrotoxin; Pentylenetetrazole; Locomotor activity; Thigmotaxis; Light-dark condition;
The dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites
Keywords: پیکروتوکسین; Recombinant GABAA receptors; Adverse CNS side effects; Picrotoxin; AIDS; Antiretroviral; BDZ; benzodiazepine; CNS; central nervous system; DMSO; dimethyl sulfoxide; DZ; diazepam; EFAV; efavirenz; FLU; flumazenil; LGICs; ligand-gated ion channels; HEK293;
Terminalia arjuna bark extract attenuates picrotoxin-induced behavioral changes by activation of serotonergic, dopaminergic, GABAergic and antioxidant systems
Keywords: پیکروتوکسین; Anxiety; Terminalia arjuna; Gene expression; Picrotoxin; Neurotransmitters; LC-MS;
Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway
Keywords: پیکروتوکسین; AED; Antiepileptic drug; CNS; Central Nervous System; PME; Pseudospondias microcarpa extract; CBZ; Carbamazepine; FMZ; Flumazenil; VPA; Valproic acid; KNUST; Kwame Nkrumah University of Science and Technology; PTZ; Pentylenetetrazole; PTX; Picrotoxin; Hz;
Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice
Keywords: پیکروتوکسین; 8-Br-PET-cGMP; 8-Bromo-β-phenyl-1, N2-ethenoguanosine-cGMP; ACSF; artificial cerebrospinal fluid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; cGMP; cyclic guanosine monophosphate; D-AP5; d-(-)-2-amino-5-phosphonopentanoic aci
Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons
Keywords: پیکروتوکسین; Kynurenic acid; Dopamine; Ventral tegmental area; Firing; Kynurenine transferase; GABA-receptor; NMDA-receptor; PF-04859989; d-Cycloserine; CGP-52432; Picrotoxin;
Emamectin is a non-selective allosteric activator of nicotinic acetylcholine receptors and GABAA/C receptors
Keywords: پیکروتوکسین; Emamectin; Ivermectin; Nicotinic receptor; GABAA/C receptor; Allosteric activation; EB; emamectin benzoate; nAChR; nicotinic acetylcholine receptor; GABA; γ-aminobutyric acid; IVM; ivermectin; PTX; picrotoxin; MCA; mecamylamine; Imax; maximal current; EC
Research reportInfralimbic cortex controls the activity of the hypothalamus-pituitary-adrenal axis and the formation of aversive memory: Effects of environmental enrichment
Keywords: پیکروتوکسین; Prefrontal cortex; Picrotoxin; Muscimol; Stress; Corticosterone; Emotional memory;
Memory impairment due to fipronil pesticide exposure occurs at the GABAA receptor level, in rats
Keywords: پیکروتوکسین; fipronil; picrotoxin; pesticide; memory behavior; GABA;
Anticonvulsant effects of ethanol stem bark extract of Lannea barteri (Anacardiaceae) in mice and chicks
Keywords: پیکروتوکسین; Lannea barteri; Epilepsy; Maximal electroshock; Pentylenetetrazole; Strychnine; Picrotoxin;
Neuropharmacological effects of carvacryl acetate on δ-aminolevulinic dehydratase, Na+, K+-ATPase activities and amino acids levels in mice hippocampus after seizures
Keywords: پیکروتوکسین; CA; carvacryl acetate; DZP; diazepam; FLU; flumazenil; GABA; δ-aminobutyric acid; PIC; picrotoxin; PTZ; pentylenetetrazol; P400; pilocarpine; δ-ALA-D; δ-aminolevulinic acid dehydratase; Anticonvulsant; Acetate; Carvacryl; Epilepsy; Mouse;
Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex
Keywords: پیکروتوکسین; ACSF; artificial cerebrospinal fluid; AP-5; dl-2-amino-5-phophonovaleric acid; APs; action potentials; DNQX; 6,7-dinitroquinoxaline-2,3-dione; EGTA; ethylene glycol tetraacetic acid; eIPSCs; evoked IPSCs; FS; fast-spiking; HEPES; 4-(2-hydroxyethyl)-1-pipe
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Keywords: پیکروتوکسین; Wnt5a; wingless-type family member 5a; NMDA; N-methyl d-aspartic acid; NO; nitric oxide; 7-NI; 7-nitroindazole; ROR2; receptor tyrosine kinase-like orphan receptor 2; sFRP-2; soluble frizzled related protein 2; DVL; Disheveled; Wnt/PCP; Wnt/planar cell po
Optogenetic inhibition of chemically induced hypersynchronized bursting in mice
Keywords: پیکروتوکسین; Epileptiform; Seizure; Optogenetics; Mouse; GABA; Picrotoxin; Bicuculline; Inhibition; NpHR; Hippocampus;
Beyond the basal ganglia: cFOS expression in the cerebellum in response to acute and chronic dopaminergic alterations
Keywords: پیکروتوکسین; 6-OHDA; 6-hydroxydopamine; DN; dentate nucleus; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; PN; pontine nuclei; SNc; substantia nigra pars compacta; SNr; SN reticulata; STN; subtalamic nucleus; cerebellum; dopamine; halo
Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus
Keywords: پیکروتوکسین; ACh; acetylcholine; ACSF; artificial cerebrospinal fluid; Atrp; atropine; BIC; bicuculline; D-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DMSO; dimethyl sulfoxide; fEPSPs; field excitatory postsynaptic potentials; HFS; high-frequency stimulation; IBI;
Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region
Keywords: پیکروتوکسین; ACSF; artificial cerebrospinal fluid; αCaMKII; α-calmodulin-dependent kinase II; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ANOVA; analysis of variance; CA1; Cornu Ammonis area 1; Cre; cAMP response element; DG; dentate gyrus;
Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity
Keywords: پیکروتوکسین; 2-AG; 2-arachidonoyl-glycerol; ACSF; artificial cerebrospinal fluid; AEA; endocannabinoid/endovanniloid anandamide; ANOVA; analysis of variance; CB; cannabinoid; CCK; cholecystokinin; CMS; chronic mild stress; CRS; chronic restraint stress; DMSO; dimethyl
Anticonvulsant effects of agomelatine in mice
Keywords: پیکروتوکسین; Agomelatine; Strychnine; Pilocarpine; Electroshock stimulation; Anticonvulsant effect; Picrotoxin; Seizure; Melatonin
Modifications of the input currents on VTA dopamine neurons following acute versus chronic cocaine exposure
Keywords: پیکروتوکسین; AMPA receptor; GABAA receptor; NMDA receptor; Ratio; Picrotoxin; ePSC; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; APV; d-(â)-2-amino-5-phosphonopentanoic acid; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; DA; dopamine; ePSC;
Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory
Keywords: پیکروتوکسین; Honeybee; Mushroom bodies; Olfactory conditioning; GABA; Glutamate; Picrotoxin
UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities
Keywords: پیکروتوکسین; Cholinesterase inhibition; Galium spurium; LC-TOF-MS; Maximum electroshock; Pentylenetetrazole; Picrotoxin;
Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract
Keywords: پیکروتوکسین; Achillea millefolium; Anti-anxiety agents; Anxiety; Apigenin; GABA antagonist; Flumazenil; Picrotoxin;
Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: Modulation by macrocyclic lactone anthelmintics and a receptor for piperazine
Keywords: پیکروتوکسین; GABA receptor; Haemonchus contortus; Piperazine; Ivermectin; Moxidectin; Picrotoxin; Dieldrin; Fipronil;
Aging impairs the control of prefrontal cortex on the release of corticosterone in response to stress and on memory consolidation
Keywords: پیکروتوکسین; Prefrontal cortex; Corticosterone; Stress; Picrotoxin; Muscimol; Inhibitory avoidance; Microinjection; Rat;
Devil's Claw-A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens
Keywords: پیکروتوکسین; 5-LOX; 5-lipo-oxygenase; 6â²-PCHG; 6â²-O-p-coumaroylharpagide; 8-PCHG; 8-p-coumaroylharpagide; BCL; Bicuculline; COX-2; cyclooxygenase-2; CREB; cAMP response element-binding; CYP; cytochrome P450; DAD; diode array detection; DPPH; 2, 2-diphenyl-1-picryl
Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo
Keywords: پیکروتوکسین; Cigarette smoke; nicotine; nicotinic acetylcholine receptors; γ-aminobutyric acid receptors; acetylcholine; airway mucus; AB/PAS; Alcian blue/periodic acid-Schiff; ALI; Air-liquid interface; GABAAR; γ-Aminobutyric acid type A receptor; GAPDH; Glycera
Brief communicationPerinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo
Keywords: پیکروتوکسین; Excitotoxicity; Non-coplanar PCBs; Picrotoxin; Hippocampus; Hippocampal slice; GABAA receptor; Seizure activity; Microelectrode array;
Iso-6-spectaline effects on convulsions induced in epilepsy models
Keywords: پیکروتوکسین; Fabaceae; open field; pentylenetetrazole; picrotoxin; senna spectabiliss;
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice
Keywords: پیکروتوکسین; Senna spectabilis; Fabaceae; Pentilenotetrazol; Picrotoxin; Open field
Research ReportGlycine-activated chloride currents of neurons freshly isolated from the prefrontal cortex of young rats
Keywords: پیکروتوکسین; Whole cell patch-clamp; Prefrontal cortex; Glycine receptor; Strychnine; Picrotoxin;
Carbamazepine inhibits distinct chemoconvulsant-induced seizure-like activity in Dugesia tigrina
Keywords: پیکروتوکسین; Planarian seizure-like activity; Dugesia tigrina; Carbamazepine; Nicotine; Picrotoxin; N-methyl-d-aspartate;
Potentiation and inhibition of glycine receptors by tutin
Keywords: پیکروتوکسین; Tutin; Glycine receptor; Ethanol; Zn2+; GABAA receptor; Picrotoxin;
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models
Keywords: پیکروتوکسین; Ethyl acetate fraction; Platonia insignis; Pilocarpine; Pentylenetetrazole; Picrotoxin; Neuroprotection; Botanicals; Antioxidants;
Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-d-aspartate receptor channels
Keywords: پیکروتوکسین; rat brain embryonic cultures; NR2 subunits; NR2B antagonists; heavy metal; in vitro development; neurotoxicity; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate; APV; d(â)-2-amino-5-phosphonopentanoic acid; DIV; days in vitro; HEPES; 4-(2-hyd
A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains
Keywords: پیکروتوکسین; GSM radiation; Picrotoxin; c-fos; GFAP
Anticonvulsant activity of DNS II fraction in the acute seizure models
Keywords: پیکروتوکسین; Delphinium nordhagenii; Pentylenetetrazole; Maximal electroshock test; Diazepam; Picrotoxin; Epilepsy
Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties
Keywords: پیکروتوکسین; α-Asarone; Seizure; Audiogenic test; Electroshock; Pentylenetetrazole; Picrotoxin; N-methyl-d-aspartate; Pilocarpine; Neuroprotection; Antioxidant; Magnesium deficiency; Epilepsy;
Prenatal ethanol exposure attenuates GABAergic inhibition in basolateral amygdala leading to neuronal hyperexcitability and anxiety-like behavior of adult rat offspring
Keywords: پیکروتوکسین; anxiety-like behavior; prenatal EtOH exposure; basolateral amygdale complex; GABA; evoked potential; dysinhibition; ACSF; artificial cerebrospinal fluid; BEC; blood ethanol contentration; BLA; basolateral amygdala complex; BMI; bicuculline methiodide; EC;