کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2539301 1122171 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice
چکیده انگلیسی

The depressant and anticonvulsant activities of iso-6-cassine (ISO) from Senna spectabilis (0.5, 1.0 and 1.5 mg/kg) injected by oral route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 30 days after the administration and at dose of 1.5 mg/kg, it reduced the remaining time of animals on Rota-rod apparatus. Additionally, ISO at doses tested was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole and picrotoxin. These results suggest possible depressant and anticonvulsant activities in mice that need further investigation.

Graphical AbstractIso-6-cassine (ISO), isolated from the leaves of Senna spectabilis var. excelsa (Schrad), showed potent depressant and anticonvulsant activity in mice models of neurodegenerative disorders.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 82, Issue 2, March 2011, Pages 255–259
نویسندگان
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