کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6276803 | 1295744 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal ethanol exposure attenuates GABAergic inhibition in basolateral amygdala leading to neuronal hyperexcitability and anxiety-like behavior of adult rat offspring
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کلمات کلیدی
MDZPPFBECEtOHBLAbasolateral amygdala complexPPIIPSPaCSFPTXHFSI/O - I / OEthanol - اتانولPopulation spike - افزایش جمعیتevoked potential - بالقوه را تحریک می کندhigh frequency stimulation - تحریک فرکانس بالاpaired-pulse facilitation - تسکین زوایای پالسیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP standard error - خطای استانداردAnxiety-like behavior - رفتار اضطراب مانندgestational day - روز بارداریpostnatal day - روز پس از زایمانBMI - شاخص توده بدنیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیbicuculline methiodide - متیکویدید bicucullinePaired-pulse inhibition - مهار زوج پالسMidazolam - میدازولامinput–output - ورودی خروجیinhibitory postsynaptic potential - پتانسیل پستانیپتیک مهارکنندهPicrotoxin - پیکروتوکسینexternal capsule - کپسول خارجیGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Prenatal exposure to a relatively high-dose ethanol (EtOH) caused anxiety-like behavior of adult male rat offspring. Previous studies have demonstrated that GABA system in the basolateral amygdala complex (BLA) is involved in the pathogensis of anxiety-related disorders. The role of GABAergic system in the BLA was investigated in anxiety-like behavior evoked by prenatal EtOH exposure. The infusion of midazolam (MDZ), a positive modulator of GABAA receptor, into the BLA prevented anxiety-like behavior in EtOH-offspring without affecting the corresponding behavior of control offspring. The data suggest that anxiety-like behavior could be causally related to increased neuronal excitability attributable to depressed GABAergic inhibition in the BLA. To test this hypothesis, evoked potential was studied using brain slices from EtOH-offspring. Potential evoked in the BLA by single stimuli applied to external capsule showed multispike responses, indicative of GABAergic disinhibition. These multiple responses were no longer evident after the perfusion with MDZ. In the slices from EtOH-offspring, paired-pulse inhibition (GABAA-dependent) was suppressed. Also, in EtOH-offspring, long-term potentiation (LTP) was induced by a single train of high frequency stimulation, which did not induce LTP in control rats. Moreover, MDZ pretreatment prevented the facilitating effect of EtOH on LTP induction. The data provide the functional evidence that prenatal EtOH exposure attenuates GABAergic inhibition in the BLA resulting in neuronal hyperexcitability and anxiety-like behavior of adult rat offspring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 3, 27 October 2010, Pages 749-757
Journal: Neuroscience - Volume 170, Issue 3, 27 October 2010, Pages 749-757
نویسندگان
R. Zhou, S. Wang, X. Zhu,