کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272310 | 1614779 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brainstem areas activated by intermittent apnea in awake unrestrained rats
ترجمه فارسی عنوان
مناطق مغزی قفسه سینه با استفاده از آپنه متناوب در موشهای بیحرکتی فعال می شوند
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کلمات کلیدی
DABCBANTSMedulla oblongataFos-immunoreactivityRVLMVLMCVLMNHSrostral ventrolateral medulla - آرام آرامObstructive apnea - آپنه انسدادیtyrosine hydroxylase - تیروزین هیدروکسیلازdiaminobenzidine - دیامینو بنزیدینnormal horse serum - سرم طبیعی اسبArterial chemoreceptors - شیمی درمانی شریانیFos-ir - فوزیventrolateral medulla - مدول ونتیلاتورcaudal ventrolateral medulla - مدولال ventrolateral کادالnucleus of the solitary tract - هسته دستگاه انفرادیHypoxia - هیپوکسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
We investigated the role of the autonomic nervous system to cardiovascular responses to obstructive apnea in awake, unrestrained rats, and measured expression of Fos induced by apnea in the brainstem. We implanted a tracheal balloon contained in a rigid tube to allow the induction of apnea without inducing pain in the trachea. During bouts of 15 s of apnea, heart rate fell from 371 ± 8 to 161 ± 11 bpm (mean ± SEM, n = 15, p < 0.01) and arterial pressure increased from 115 ± 2 to 131 ± 4 mmHg (p < 0.01). Bradycardia was due to parasympathetic activity because it was blocked by the muscarinic antagonist, methylatropine. The pressor response was due to vasoconstriction caused by sympathetic activation because it was blocked by the α1 antagonist, prazosin. Apnea induced Fos expression in several brainstem areas involved in cardiorespiratory control such as the nucleus of the solitary tract (NTS), ventrolateral medulla (VLM), and pons. Ligation of the carotid body artery reduced apnea-induced bradycardia, blocked heart rate responses to i.v. injection of cyanide, reduced Fos expression in the caudal NTS, and increased Fos expression in the rostral VLM. In conclusion, apnea activates neurons in regions that process signals from baroreceptors, chemoreceptors, pulmonary receptors, and regions responsible for autonomic and respiratory activity both in the presence and absence of carotid chemoreceptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 297, 25 June 2015, Pages 262-271
Journal: Neuroscience - Volume 297, 25 June 2015, Pages 262-271
نویسندگان
C.B. Ferreira, G.H. Schoorlemmer, M.V. Rossi, A.C. Takakura, B.F. Barna, T.S. Moreira, S.L. Cravo,