کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272447 | 1614772 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Compensatory projections of primary sensory fibers in lumbar spinal cord after neonatal thoracic spinal transection in rats
ترجمه فارسی عنوان
پیش بینی های جسمی فیبرهای حسی اولیه در نخاع کمری بعد از برداشتن نخاع قفسه سینه نوزاد در موش صحرایی
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کلمات کلیدی
PBSDRGVHMTBSCpGBasso, Beattie, BresnahanBDAVHLdorsal root ganglion - گانگلیون ریشه پشتیTris-buffered saline - تریس بافر شورDextran amine - دکستران آمینBBB - سد خونی مغزیSpinal cord - طناب نخاعیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریintermediate zone - منطقه متوسطCentral Pattern Generator - ژنراتور الگوی مرکزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Complete spinal transection in adult rats results in poor recovery of hind limb function, whereas significant spontaneous recovery can occur following spinal cord transection in rat neonates. The mechanisms underlying the recovery, however, are poorly understood. Recent studies in rodents suggested that the recovery is not due to axonal regeneration, but rather due to reorganization of the neural circuits in the spinal cord below the injury site, including central pattern generators. Few studies have reported histological evidence for changes in the primary sensory fibers or terminals. Thus, in the present study, we transected spinal cords of rats at thoracic level 8 at postnatal day 5. Four weeks after the injury, biotinylated-dextran amine (BDA), an anterograde tracer, was injected into the dorsal root ganglion of the lumbar spinal cord to examine the localization of sensory fibers and their terminal buttons in the spinal cord. BDA-positive axons in the rat spinal cord following neonatal spinal transection (neo ST) were longer than those in sham-operated or normal rats. The number of terminal buttons was also higher in spinal cords of neo ST rats compared with sham-operated or normal rats. These findings suggest that sensory fibers project more strongly and make more synapses following neo ST to compensate for the lack of supraspinal projections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 304, 24 September 2015, Pages 349-354
Journal: Neuroscience - Volume 304, 24 September 2015, Pages 349-354
نویسندگان
M. Takiguchi, Y. Atobe, T. Kadota, K. Funakoshi,