کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272502 | 1614778 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potentiation of tonic GABAergic inhibition by activation of postsynaptic kainate receptors
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کلمات کلیدی
EGTAAP-5NMDARIPSCTTXHEPES4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acidD-(−)-2-amino-5-phosphonopentanoic acid - D - (-) - 2-amino-5-phosphonopentanoic acidTHIP - آنethylene glycol tetraacetic acid - اتیلن گلیکول تتراستیک اسیدkainic acid - اسید کرییکtetrodotoxin - تترو دوتوکسین long-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP inhibitory postsynaptic current - جریان پستانیپتیک مهارکنندهTonic inhibition - مهار تونیکPatch-clamp - پچ گیرKar - کارN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartateKainate receptor - گیرنده کینات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Presynaptic kainate-type glutamate ionotropic receptors (KARs) that mediate either the depression or the facilitation of GABA release have been intensively studied. Little attention has been given to the modulation of GABAA receptors (GABAARs) by postsynaptic KARs. Recent studies suggest that two GABAAR populations, synaptic (sGABAAR) and extrasynaptic (eGABAAR) GABAARs, mediate phasic and tonic forms of inhibition, respectively. Tonic inhibition plays an important role in the excitability of neuronal circuits and the occurrence of epileptic seizures. For this study, we are the first to report that the activation of postsynaptic KARs by the KAR agonist, Kainic acid (KA, 5 μM), enhanced tonic inhibition by potentiating eGABAARs. KA enhanced THIP-induced eGABAAR currents and prolonged the rise and decay time of muscimol-induced sGABAAR/eGABAAR currents, but also depressed the amplitude of evoked inhibitory postsynaptic currents (IPSCs), unitary IPSCs (uIPSCs), and muscimol-induced sGABAAR/eGABAAR currents. The PKC inhibitor, staurosporine (1 μM), in the patch pipette solution fully blocked the KA-induced potentiation of tonic inhibition, suggesting the involvement of an intracellular PKC pathway. Our study suggests that the activation of postsynaptic KARs potentiates eGABAARs but depresses sGABAARs. By activating postsynaptic KARs, synaptically released glutamate depresses phasic inhibition to facilitate neuronal plasticity, but potentiates tonic inhibition to protect neurons from over-excitation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 298, 9 July 2015, Pages 448-454
Journal: Neuroscience - Volume 298, 9 July 2015, Pages 448-454
نویسندگان
L. Jiang, D. Kang, J. Kang,