کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272759 | 1614785 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The basolateral nucleus of the amygdala mediates caloric sugar preference over a non-caloric sweetener in mice
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کلمات کلیدی
PBSdorsoventralNeuNANCOVABLACeA - CEAAmygdala - آمیگدال، بادامهphosphate buffer - بافر فسفاتanalyses of variance - تجزیه و تحلیل واریانسanalysis of covariance - تجزیه و تحلیل کوواریانسANOVA - تحلیل واریانس Analysis of variancemediolateral - دو طرفهSweetener - شیرین کنندهfood restriction - محدودیت غذاPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریcentral nucleus of the amygdala - هسته مرکزی آمیگدالbasolateral nucleus of the amygdala - هسته نزولی amygdalaneuronal nuclei - هسته های نورونیanteroposterior - پیشاپیشCalorie - کالری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The basolateral nucleus of the amygdala mediates caloric sugar preference over a non-caloric sweetener in mice The basolateral nucleus of the amygdala mediates caloric sugar preference over a non-caloric sweetener in mice](/preview/png/6272759.png)
چکیده انگلیسی
Neurobiological and genetic mechanisms underlying increased intake of and preference for nutritive sugars over non-nutritive sweeteners are not fully understood. We examined the roles of subnuclei of the amygdala in the shift in preference for a nutritive sugar. Food-deprived mice alternately received caloric sucrose (1.0Â M) on odd-numbered training days and a non-caloric artificial sweetener (2.5Â mM saccharin) on even-numbered training days. During training, mice with sham lesions of the basolateral (BLA) or central (CeA) nucleus of the amygdala increased their intake of 1.0Â M sucrose, but not saccharin. Trained mice with sham lesions showed a significant shift in preference toward less concentrated sucrose (0.075Â M) over the saccharin in a two-bottle choice test, although the mice showed an equivalent preference for these sweeteners before training. No increased intake of or preference for sucrose before and after the alternating training was observed in non-food-deprived mice. Excitotoxic lesions centered in the BLA impaired the increase in 1.0Â M sucrose intake and shift in preference toward 0.075Â M sucrose over saccharin. Microlesions with iontophoretic excitotoxin injections into the CeA did not block the training-dependent changes. These results suggest that food-deprived animals selectively shift their preference for a caloric sugar over a non-caloric sweetener through the alternate consumption of caloric and non-caloric sweet substances. The present data also suggest that the BLA, but not CeA, plays a role in the selective shift in sweetener preference.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 291, 16 April 2015, Pages 203-215
Journal: Neuroscience - Volume 291, 16 April 2015, Pages 203-215
نویسندگان
Y. Yasoshima, H. Yoshizawa, T. Shimura, T. Miyamoto,