کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272805 | 1614793 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?
ترجمه فارسی عنوان
پلاستیک کورکورانه بزرگسالان پس از آسیب: جمع آوری مکانیزم های بحرانی
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کلمات کلیدی
TNFαVEPsthalamocorticalN-methyl-d-aspartateNMDAODP - RIPlong-term depression - افسردگی طولانی مدتlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP tumor necrosis factor-alpha - تومور نکروز عامل آلفاCritical period - دوره انتقادیfast-spiking - سریع اسپایکینگLTD - محدودmonocular deprivation - محرومیت یکنواختVisually evoked potentials - پتانسیل بصری منجر شدocular dominance plasticity - پوسیدگی غلظت چشمPirB - پیرب
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
A primary goal of research on developmental critical periods (CPs) is the recapitulation of a juvenile-like state of malleability in the adult brain that might enable recovery from injury. These ambitions are often framed in terms of the simple reinstatement of enhanced plasticity in the growth-restricted milieu of an injured adult brain. Here, we provide an analysis of the similarities and differences between deprivation-induced and injury-induced cortical plasticity, to provide for a nuanced comparison of these remarkably similar processes. As a first step, we review the factors that drive ocular dominance plasticity in the primary visual cortex of the uninjured brain during the CP and in adults, to highlight processes that might confer adaptive advantage. In addition, we directly compare deprivation-induced cortical plasticity during the CP and plasticity following acute injury or ischemia in mature brain. We find that these two processes display a biphasic response profile following deprivation or injury: an initial decrease in GABAergic inhibition and synapse loss transitions into a period of neurite expansion and synaptic gain. This biphasic response profile emphasizes the transition from a period of cortical healing to one of reconnection and recovery of function. Yet while injury-induced plasticity in adult shares several salient characteristics with deprivation-induced plasticity during the CP, the degree to which the adult injured brain is able to functionally rewire, and the time required to do so, present major limitations for recovery. Attempts to recapitulate a measure of CP plasticity in an adult injury context will need to carefully dissect the circuit alterations and plasticity mechanisms involved while measuring functional behavioral output to assess their ultimate success.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 283, 26 December 2014, Pages 4-16
Journal: Neuroscience - Volume 283, 26 December 2014, Pages 4-16
نویسندگان
M. Nahmani, G.G. Turrigiano,