کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272860 | 1614792 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extracellular matrix molecules exhibit unique expression pattern in the climbing fiber-generating precerebellar nucleus, the inferior olive
ترجمه فارسی عنوان
مولکول های ماتریکس خارج سلولی الگوی بیان منحصر به فرد را در هسته پرتوی سلول های تولید کننده فیبر کوهنوردی، زیتون زیرسطحی
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کلمات کلیدی
NRSdorsal capbHABPHapln1biotinylated hyaluronan binding proteindorsal accessory oliveNHSMAOCSPGsECMPNNPBSACSIgGNGSDMCCBSA - BSAbovine serum albumin - آلبومین سرم گاوimmunoglobulin G - ایمونوگلوبولین GPerineuronal net - خالص PerineuronalDAO - دائوCNS - دستگاه عصبی مرکزیmedial accessory olive - زیتون لوازم جانبی پزشکیinferior olive - زیتون ناقصnormal horse serum - سرم طبیعی اسبnormal goat serum - سرم طبیعی بزnormal rabbit serum - سرم طبیعی خرگوشcentral nervous system - سیستم عصبی مرکزیExtracellular matrix - ماتریکس خارج سلولیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریHyaluronan - هیالورونانChondroitin sulfate proteoglycans - پروستاگلایسینهای سولفات کلسترولGlycoprotein - گلیکوپروتئین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Extracellular matrix (ECM) accumulates around different neuronal compartments of the central nervous system (CNS) or appears in diffuse reticular form throughout the neuropil. In the adult CNS, the perineuronal net (PNN) surrounds the perikarya and dendrites of various neuron types, whereas the axonal coats are aggregations of ECM around the individual synapses, and the nodal ECM is localized at the nodes of Ranvier. Previous studies in our laboratory demonstrated on rats that the heterogeneous distribution and molecular composition of ECM is associated with the variable cytoarchitecture and hodological organization of the vestibular nuclei and may also be related to their specific functions in gaze and posture control as well as in the compensatory mechanisms following vestibular lesion. Here, we investigated the ECM expression pattern in the climbing fiber-generating inferior olive (IO), which is functionally related to the vestibular nuclei. By using histochemical and immunohistochemical methods, the most characteristic finding was the lack of PNNs, presumably due to the absence of synapses on the perikarya and proximal dendrites of IO neurons. On the other hand, the darkly stained dots or ring-like structures in the neuropil might represent the periaxonal coats around the axon terminals of olivary synaptic glomeruli. We have observed positive ECM reaction for the hyaluronan, tenascin-R, hyaluronan and proteoglycan link protein 1 (HAPLN1) and various chondroitin sulfate proteoglycans. The staining intensity and distribution of ECM molecules revealed a number of differences between the functionally different subnuclei of IO. We hypothesized that the different molecular composition and intensity differences of ECM reaction is associated with different control mechanisms of gaze and posture control executed by the visuomotor-vestibular, somatosensory and integrative subnuclei of the IO.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 284, 22 January 2015, Pages 412-421
Journal: Neuroscience - Volume 284, 22 January 2015, Pages 412-421
نویسندگان
S. Kecskes, B. Gaál, Ã. Rácz, A. Birinyi, A. Hunyadi, C. Matesz,