کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6273128 | 1614790 | 2015 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Organization of the human superior olivary complex in 15q duplication syndromes and autism spectrum disorders
ترجمه فارسی عنوان
سازمان مجتمع ایلواری فوق العاده انسان در سندرم های تکثیر 15 قسمتی و اختلالات طیف اوتیسم
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کلمات کلیدی
MSOLNTBLSOVNTBSPONMNTBAutism spectrum disorder - اختلالات طیف اوتیسم گروهیEctopic - اضطرابیtrapezoid body - بدن ترسناکlateral superior olive - زیتون برتر جانبیmedial superior olive - زیتون عالیBrainstem - ساقه مغزSOC - سیستم روی یک تراشهAuditory - شنواییsuperior olivary complex - مجتمع عالی ایلواریASD - نقص سپتوم یا دیوارهی دهلیزیsuperior paraolivary nucleus - هسته paraolivary برترlateral nucleus of the trapezoid body - هسته جانبی بدن بدنه استventral nucleus of the trapezoid body - هسته شکمی از بدن استپزوئیدmedial nucleus of the trapezoid body - هسته مرکزی بدن تراپزیfacial nucleus - هسته چهرهCochlear Nucleus - هسته کچلر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a number of behavioral and social features. Although the etiology of most cases of ASD is idiopathic, a significant number of cases can be attributed to genetic causes, such as chromosome 15q duplications [dup(15q)]. Recent neuropathological investigations have provided evidence for distinct patterns of heterotopias and dysplasias in ASD and subjects with both ASD and dup(15q). Individuals with ASD characteristically have hearing difficulties and we have previously demonstrated significant and consistent hypoplasia in a number of auditory brainstem nuclei in subjects with ASD. Herein, we compare results from a morphometric investigation of auditory brainstem nuclei in subjects with ASD, dup(15q) and controls. Our observations in subjects with ASD support our previous reports. However, in subjects with dup(15q), we find significantly fewer neurons and in many nuclei, neurons were significantly smaller than in ASD subjects. Finally, we find a notably higher incidence of ectopic neurons in dup(15q). These results suggest that in the brainstem, these neuropathological conditions may evolve from some of the same developmental errors but are distinguished on microscopic features.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 286, 12 February 2015, Pages 216-230
Journal: Neuroscience - Volume 286, 12 February 2015, Pages 216-230
نویسندگان
R. Lukose, K. Beebe, R.J. Jr.,