کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6273297 | 1614794 | 2014 | 10 صفحه PDF | دانلود رایگان |
- There are key areas within the striatum that receive convergent terminals from different functional cortical regions.
- Subpopulations of dopamine neurons are involved in different functions including reward, cognition and motor control.
- The striato-nigra system is a key factor in integrating information across functional domains.
The midbrain dopamine (DA) neurons play a central role in developing appropriate goal-directed behaviors, including the motivation and cognition to develop appropriate actions to obtain a specific outcome. Indeed, subpopulations of DA neurons have been associated with these different functions: the mesolimbic, mesocortical, and nigrostriatal pathways. The mesolimbic and nigrostriatal pathways are an integral part of the basal ganglia through its reciprocal connections to the ventral and dorsal striatum respectively. This chapter reviews the connections of the midbrain DA cells and their role in integrating information across limbic, cognitive and motor functions. Emphasis is placed on the interface between these functional domains within the striatum through corticostriatal connections, through the striato-nigro-striatal connection, and through the lateral habenula projection to the midbrain.
Journal: Neuroscience - Volume 282, 12 December 2014, Pages 248-257