کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6273941 1614809 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat
ترجمه فارسی عنوان
فعال سازی دیفرانسیل قشر پیش مغلوب و آمیگدال پس از استرس روانی و تنش کولورکتال در موش های جدا شده از مادر
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Maternal separated (MS) animals have increased c-fos expression after CRD compared to NS rats in corticoamygdalar areas.
- Increased c-fos expression is also found when the MS CRD group is compared to controls for the same brain areas.
- Decreased locomotion in MS rats is not associated with differential brain activation in the areas analyzed.

Visceral hypersensitivity is a hallmark of many clinical conditions and remains an ongoing medical challenge. Although the central neural mechanisms that regulate visceral hypersensitivity are incompletely understood, it has been suggested that stress and anxiety often act as initiating or exacerbating factors. Dysfunctional corticolimbic structures have been implicated in disorders of visceral hypersensitivity such as irritable bowel syndrome (IBS). Moreover, the pattern of altered physiological responses to psychological and visceral stressors reported in IBS patients is also observed in the maternally separated (MS) rat model of IBS. However, the relative contribution of various divisions within the cortex to the altered stress responsivity of MS rats remains unknown. The aim of this study was to analyze the cellular activation pattern of the prefrontal cortex and amygdala in response to an acute psychological stressor (open field) and colorectal distension (CRD) using c-fos immunohistochemistry. Several corticoamygdalar structures were analyzed for the presence of c-fos-positive immunoreactivity including the prelimbic cortex, infralimbic cortex, the anterior cingulate cortex (both rostral and caudal) and the amygdala. Our data demonstrate distinct activation patterns within these corticoamygdalar regions including differential activation in basolateral versus central amygdala following exposure to CRD but not the open field stress. The identification of this neuronal activation pattern may provide further insight into the neurochemical pathways through which therapeutic strategies for IBS could be derived.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 267, 16 May 2014, Pages 252-262
نویسندگان
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