کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274431 | 1614826 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stress-induced metaplasticity: From synapses to behavior
ترجمه فارسی عنوان
متاپلستیک ناشی از استرس: از سیناپس به رفتار
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کلمات کلیدی
HDACsCREBBLADNA methyl transferaseDnmtMPFCMecp2CBPbasolateral amygdala - amygdala basolateralNFκB - NFKBStress - استرس یا فشار روانیlong-term depression - افسردگی طولانی مدتlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Cognition - شناختdentate gyrus - شکنج دندانه دارnuclear factor kappa B - فاکتور هسته ای کاپا Bmedial prefrontal cortex - قشر غده پروسترولmetaplasticity - متاپلستیکLTD - محدودhistone deacetylases - هیستون deacetylasesHistone acetyltransferase - هیستون استیل ترانسفرازCREB binding protein - پروتئین اتصال CREBSynaptic plasticity - پلاستیسیته سیناپسیHAT - کلاهMineralocorticoid receptor - گیرنده مینرالوکورتیکوئید glucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Synaptic plasticity, specifically long-term potentiation and long-term depression, is thought to be the underlying cellular mechanism for learning and memory processes in the brain. About two decades ago a new concept was introduced, namely metaplasticity, which comprises changes that modify the properties of synaptic plasticity due to a priming or preconditioning event. While metaplasticity was initially defined and studied predominantly on a synaptic and cellular level, it soon became apparent that the term could also be very useful to describe plasticity changes on a more global level, including environmental stressors as priming events and altered behavior as outcome measures. We consider here whether it is helpful to conceptualize these latter effects as “behavioral metaplasticity”, and in which sense this view fits into the original concept of metaplasticity. By integrating the literature on environmental effects on plasticity, especially stress, plus developmental aspects as well as genetic and epigenetic modifications, we shape the framework in which the term “behavioral metaplasticity” should be considered and discuss research directions that can help to unravel the mechanisms involved in both synaptic and behavioral metaplasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 112-120
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 112-120
نویسندگان
M.V. Schmidt, W.C. Abraham, M. Maroun, O. Stork, G. Richter-Levin,