کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274461 | 1614826 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Day-night differences in neural activation in histaminergic and serotonergic areas with putative projections to the cerebrospinal fluid in a diurnal brain
ترجمه فارسی عنوان
تفاوت های روز و شب در فعال سازی عصبی در مناطق هیستامینرژی و سروتونرژیک با پیش بینی های احتمالی به مایع مغزی نخاعی در مغز روزانه
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کلمات کلیدی
PBStriton-XGrass ratTMMLDRVTMPLPSCN5HTNDSDTMFOSLSDTBSNGSICCCTBImmunocytochemistry - ایمونوسیتوشیمیphosphate buffer - بافر فسفاتlateral ventricle - بطن جانبیthird ventricle - بطن سومfourth ventricle - بطن چهارمTris-buffered saline - تریس بافر شورcircadian - دیروزDorsal raphé - رفسنجی پشتیMedian raphe - روحانی متوسطZeitgeber time - زمان تایمرnormal goat serum - سرم طبیعی بزnormal donkey serum - سرم عسل طبیعیSerotonin - سروتونینPVN - مالیات بر ارزش افزودهCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیSUM - مبلغPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریmedian eminence - مدرنیتهSupramammillary nucleus - هسته SupramammillaryTuberomammillary nucleus - هسته سلول های بنیادیlateral septal nucleus, dorsal part - هسته سپتوم جانبی، قسمت پشتیparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسSuprachiasmatic nucleus - هستههای سوپراکیاسماتیکHistamine - هیستامینChoroid plexus - پیوند کوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
In nocturnal rodents, brain areas that promote wakefulness have a circadian pattern of neural activation that mirrors the sleep/wake cycle, with more neural activation during the active phase than during the rest phase. To investigate whether differences in temporal patterns of neural activity in wake-promoting regions contribute to differences in daily patterns of wakefulness between nocturnal and diurnal species, we assessed Fos expression patterns in the tuberomammillary (TMM), supramammillary (SUM), and raphe nuclei of male grass rats maintained in a 12:12 h light-dark cycle. Day-night profiles of Fos expression were observed in the ventral and dorsal TMM, in the SUM, and in specific subpopulations of the raphe, including serotonergic cells, with higher Fos expression during the day than during the night. Next, to explore whether the cerebrospinal fluid is an avenue used by the TMM and raphe in the regulation of target areas, we injected the retrograde tracer cholera toxin subunit beta (CTB) into the ventricular system of male grass rats. While CTB labeling was scarce in the TMM and other hypothalamic areas including the suprachiasmatic nucleus, which contains the main circadian pacemaker, a dense cluster of CTB-positive neurons was evident in the caudal dorsal raphe, and the majority of these neurons appeared to be serotonergic. Since these findings are in agreement with reports for nocturnal rodents, our results suggest that the evolution of diurnality did not involve a change in the overall distribution of neuronal connections between systems that support wakefulness and their target areas, but produced a complete temporal reversal in the functioning of those systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 352-363
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 352-363
نویسندگان
A. Castillo-Ruiz, A.J. Gall, L. Smale, A.A. Nunez,