کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274468 | 1614826 | 2013 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
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کلمات کلیدی
TBZHuntington’sTJMVLsVMAT-2c-fosDABPBSDMSO - DMSOAdenosine - آدنوزینelectromyographic - الکترومیوگرافیEMG - الکترومیوگرافیHuntington’s disease - بیماری هانتینگتونTetrabenazine - تتراپرانازینanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetremor - ترمور یا لرزشDopamine - دوپامینdiaminobenzidine - دیامینو بنزیدینDimethylsulfoxide - دیمتیل سولفواکسیدPhosphate buffered saline - فسفات بافر شورknockout - ناکاوتnorepinephrine - نوراپی نفرینParkinson’s - پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor](/preview/png/6274468.png)
چکیده انگلیسی
Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington's disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience parkinsonian side effects. The present studies were conducted to investigate the ability of TBZ to induce tremulous jaw movements (TJMs), which are a rodent model of parkinsonian tremor, and to determine if interference with adenosine A2A receptor transmission can attenuate TJMs and other motor effects of TBZ. In rats, TBZ (0.25-2.0Â mg/kg) significantly induced TJMs, which primarily occurred in the 3.0-7.5-Hz frequency range. The adenosine A2A antagonist MSX-3 (1.25-10.0Â mg/kg) significantly attenuated the TJMs induced by 2.0Â mg/kg TBZ in rats, and also significantly reduced the display of catalepsy and locomotor suppression induced by TBZ. In mice, TBZ (2.5-10.0Â mg/kg) dose dependently induced TJMs, and adenosine A2A receptor knockout mice showed significantly fewer TJMs compared to wild-type controls. MSX-3 (2.5-10.0Â mg/kg) also significantly reduced TBZ-induced TJMs in CD1 mice. To provide a cellular marker of these pharmacological conditions, we examined c-Fos expression in the ventrolateral neostriatum (VLS). TBZ (2.0Â mg/kg) significantly increased the number of c-Fos-positive cells in the VLS, which is indicative of reduced DA D2 receptor transmission, and 10.0Â mg/kg MSX-3 significantly attenuated the TBZ-induced c-Fos expression. These results indicate that TBZ induces tremor as measured by the TJM model, and that pharmacological antagonism and genetic deletion of adenosine A2A receptors are capable of attenuating this oral tremor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 507-519
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 507-519
نویسندگان
S.J. Podurgiel, E.J. Nunes, S.E. Yohn, J. Barber, A. Thompson, M. Milligan, C.A. Lee, L. López-Cruz, M. Pardo, O. Valverde, C. Lendent, Y. Baqi, C.E. Müller, M. Correa, J.D. Salamone,