کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274479 | 1614826 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: Glutamate N2A/B/D [GluRε1/2/4] subtypes and the GABA synthesizing enzyme GAD65
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کلمات کلیدی
S.E.M.SKF 83959GAD65ANCOVAHET - ITHuntington’s disease - بیماری هانتینگتونParkinson’s disease - بیماری پارکینسونanalysis of covariance - تجزیه و تحلیل کوواریانسorofacial movements - جنبش های ارتوپسیstandard error of the mean - خطای استاندارد میانگینDopamine - دوپامینMutant mice - موش های جهش یافتهknockout - ناکاوتwild-type - نوع وحشیheterozygous - هتروزیگوتVehicle - وسیله نقلیهGABA - گاباGlutamate decarboxylase - گلوتامات دکربوکسیلازdopamine D1 receptors - گیرنده های D1 Dopamine
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To investigate the role of glutamate receptor subtypes and GABA in orofacial function, six individual topographies of orofacial movement, both spontaneous and induced by the dopamine D1-like receptor agonist [R/S]-3-methyl-6-chloro-7,8-dihydroxy-1-[3-methyl-phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine (SKF 83959), were quantified in mutant mice with deletion of (a) GluN2A, B or D receptors, and (b) the GABA synthesizing enzyme, 65-kD isoform of glutamate decarboxylase (GAD65). In GluN2A mutants, habituation of head movements was disrupted and vibrissae movements were reduced, with an overall increase in locomotion; responsivity to SKF 83959 was unaltered. In GluN2B mutants, vertical and horizontal jaw movements and incisor chattering were increased, with an overall decrease in locomotion; under challenge with SKF 83959, head and vibrissae movements were reduced. In GluN2D mutants, horizontal jaw movements, incisor chattering and vibrissae movements were increased, with reduced tongue protrusions and no overall change in locomotion; under challenge with SKF 83959, horizontal jaw movements were increased. In GAD65 mutants, vertical jaw movements were increased, with disruption to habituation of locomotion; under challenge with SKF 83959, vertical and horizontal jaw movements and incisor chattering were decreased. Effects on orofacial movements differed from their effects on regulation of overall locomotor behavior. These findings (a) indicate novel, differential roles for GluN2A, B and D receptors and for GAD65-mediated GABA in the regulation of individual topographies of orofacial movement and (b) reveal how these roles differ from and/or interact with the established role of D1-like receptors in pattern generators and effectors for such movements.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 743-754
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 743-754
نویسندگان
K. Tomiyama, R. Kato, Y. Hara, M. Kobayashi, M. Mishina, Y. Yanagawa, A. Kinsella, N. Koshikawa, J.L. Waddington,