کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274532 | 1614826 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats
ترجمه فارسی عنوان
نقش سولفید هیدروژن در درمان درد در موشهای غیر دیابتی و دیابتی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Contrariwise, hydroxylamine (HA, a CBS inhibitor) and dl-propargylglycine (PPG, a CSE inhibitor) decreased formalin-induced nociceptive behavior in both experimental groups. In addition, an ineffective dose of HA and PPG partially prevented the l-cysteine-induced hyperalgesia in diabetic and non-diabetic rats. Interestingly, HA and PPG were three order of magnitude more potent in diabetic rats respect to non-diabetic rats, whereas NaHS was ten times more potent in the streptozotocin-diabetic group. Nine to 11Â weeks after diabetes induction, tactile allodynia was observed in the streptozotocin-injected rats. On this condition, subcutaneous administration of PPG or HA reduced tactile allodynia in diabetic rats. Paradoxically, H2S levels were decreased in nerve sciatic, dorsal root ganglion and spinal cord, but not paw nor blood plasma, during diabetes-associated peripheral neuropathy development. Collectively, results suggest that H2S synthesized by CBS and CSE participate in formalin-induced nociception in diabetic and non-diabetic rats, as well as; in tactile allodynia in streptozotocin-injected rats. In addition, data seems to indicate that diabetic rats are more sensible to H2S-induced hyperalgesia than normoglycemic rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 786-797
Journal: Neuroscience - Volume 250, 10 October 2013, Pages 786-797
نویسندگان
M.E. Velasco-Xolalpa, P. Barragán-Iglesias, J.E. Roa-Coria, B. GodÃnez-Chaparro, F.J. Flores-Murrieta, J.E. Torres-López, C.I. Araiza-Saldaña, A. Navarrete, H.I. Rocha-González,