کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274562 | 1614830 | 2013 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Priming stimulation of basal but not lateral amygdala affects long-term potentiation in the rat dentate gyrus in vivo
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کلمات کلیدی
PFCcentral medialNAccMPFCCEMLSDbasolateral amygdala - amygdala basolateralEPSP - epspilong-term depression - افسردگی طولانی مدتlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Emotional memory - حافظه احساسیdentate gyrus - شکنج دندانه دارprefrontal cortex - قشر prefrontalmedial prefrontal cortex - قشر غده پروسترولlocus coeruleus - لوکوس سیرولئوسLTD - محدودRat - موش صحراییNucleus accumbens - هسته accumbensHippocampus - هیپوکامپ early growth response-1 - پاسخ سریع رشد 1Long-term potentiation (LTP) - پتانسیل بلند مدت (LTP)excitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The amygdaloid complex, or amygdala, has been implicated in assigning emotional significance to sensory information and producing appropriate behavioral responses to external stimuli. The lateral and basal nuclei (lateral and basal amygdala), which are termed together as basolateral amygdala, play a critical role in emotional and motivational learning and memory. It has been established that the basolateral amygdala activation by behavioral manipulations or direct electrical stimulation can modulate hippocampal long-term potentiation (LTP), a putative cellular mechanism of memory. However, the specific functional role of each subnucleus in the modulation of hippocampal LTP has not been studied yet, even though studies have shown cytoarchitectural differences between the basal and lateral amygdala and differences in the connections of each one of them to other brain areas. In this study we have tested the effects of lateral or basal amygdala pre-stimulation on hippocampal dentate gyrus LTP, induced by theta burst stimulation of the perforant path, in anesthetized rats. We found that while priming stimulation of the lateral amygdala did not affect LTP of the dentate gyrus, priming stimulation of the basal amygdala enhanced the LTP response when the priming stimulation was relatively weak, but impaired it when it was relatively strong. These results show that the basal and lateral nuclei of the amygdala, which have been already shown to differ in their anatomy and connectivity, may also have different functional roles. These findings raise the possibility that the lateral and basal amygdala differentially modulate memory processes in the hippocampus under emotional and motivational situations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 246, 29 August 2013, Pages 13-21
Journal: Neuroscience - Volume 246, 29 August 2013, Pages 13-21
نویسندگان
Z. Li, G. Richter-Levin,