Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood

► Perinatal high-fat diet increases anxiety and alters corticosteroid levels. ► Perinatal high-fat diet increases corticosteroid receptor expression in amygdala. ► Perinatal high-fat diet alters limbic pro- and anti-inflammatory gene expression. ► Glucocorticoid signaling in response to high-fat diet is sexually dimorphic.