Disruption of cerebellar cholinergic system in hypoxic neonatal rats and its regulation with glucose, oxygen and epinephrine resuscitations

► Cerebellar muscarinic M1/2/3 receptor was decreased due to neonatal hypoxia. ► Acetylcholine metabolism was also disturbed - leading to metabolic shift. ► Glucose resuscitation, alone and with oxygen, reversed the cholinergic alterations. ► Common clinical practice of 100% oxygen or epinephrine upset the cholinergic system. ► This highlights the importance of glucose supplementation in neonatal care to hypoxia.