Intrapallidal administration of 6-hydroxydopamine mimics in large part the electrophysiological and behavioral consequences of major dopamine depletion in the rat

► Intrapallidal injection of 6-OHDA results in motor deficits. ► Intrapallidal injection of 6-OHDA increases burst activity in STN neurons. ► Intrapallidal injection of 6-OHDA increases irregular activity in SNr neurons.