A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus

► When given at 30 min, VPA and DZP were ineffective against pilocarpine-induced ESE. ► SPD, an amide derivative of VPA, suppressed benzodiazepine-resistant ESE. ► SPD was as efficacious as propofol and pentobarbital, even when given at 60 min. ► VCD, an SPD homolog, was also effective at 30 min.