Glutamate modulates resting state activity in the perigenual anterior cingulate cortex - A combined fMRI-MRS study

► Combination of functional magnetic resonance imaging and spectroscopy. ► Investigation of nineteen healthy subjects. ► Relationship between resting state activity in the anterior cingulate and glutamate. ► Implications for the biochemical basis of resting state activity. ► Findings are relevant for the pathogenesis of major depressive disorder.