Neurovascular saturation thresholds under high intensity auditory stimulation during wake

► We measured auditory-evoked electrical and hemodynamic responses during wake. ► We varied the stimulus intensity to investigate potential perfusion limits. ► At higher intensity stimulation, the evoked electrical response size increased. ► At higher intensity stimulation, the evoked hemodynamic response size plateaued. ► There may be decreased vascular compliance during wake, limiting blood perfusion.