High frequency stimulation alters motor maps, impairs skilled reaching performance and is accompanied by an upregulation of specific GABA, glutamate and NMDA receptor subunits

► High frequency stimulation enlarges motor maps and lowers movement thresholds. ► High frequency stimulation impairs skilled motor learning and alters motor map expression. ► Reach training is associated with altered expression of GABA, glutamate and NMDA receptor subunits.