Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat

▶5HT's role in peripheral TRPV1-evoked thermal hyperalgesia in the rat hind paw. ▶Examined changes in thermal sensitivity following peripheral serotonergic treatment. ▶5HT pretreatment enhances TRPV1-evoked thermal hyperalgesia in male and female rats. ▶Attenuated with peripheral pretreatment with ketanserin, graniestron, and sumatriptan. ▶In vivo evidence supporting reported enhancing role of 5HT on TRPV1 function in vitro.