Reciprocal sympatho-sensory control: functional role of nucleotides and calcitonin gene-related peptide in a peripheral neuroeffector junction

▶Sympatho-sensory control in a peripheral neuroeffector junction regulates motor tone. ▶CGRP inhibited sympathetic-transmitter release, reducing tissue motor tone. ▶H-89 blocked CGRP-induced presynaptic inhibition through cAMP/PKA signaling pathway. ▶Capsaicin mimicked the CGRP inhibitory action and reduced tissue tone. ▶P2Y1/P2Y2 ATP receptors inhibited ir-CGRP release and increased tissue tone.87