Keywords: 007; 8-(4-chlorophenylthio)-2â²-O-methyladenosine-3â²,5â²-cyclic monophosphorothioate, Sp-isomer; BAY; 2-(3,4-dimethoxybenzyl)-7-{(1R)-1-[(1R)-1-hydroxyethyl]-4-phenylbutyl}-5-methyllimidazo[5,1-f][1,2,4]triazin-4(3H)-one (BAY-60-7550); BK channels; la
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Testosterone rapidly increases Ca2+-activated K+ currents causing hyperpolarization in human coronary artery endothelial cells
Keywords: ANOVA; analysis of variance; BKCa; large conductance Ca2+-activated K+ channel; DHT; dihydrotestosterone; DIDS; 4,4â²-diisothiocyanatostilbene-2,2â²-disulfonic acid; DMSO; dimethyl sulfoxide; EET; epoxyeicosatrienoic acid; EGTA; ethylene glycol-bis(β-a
Kinetic properties and adrenergic control of TREK-2-like channels in rat medial prefrontal cortex (mPFC) pyramidal neurons
Keywords: 8-Br-cAMP; 8-bromoadenosine 3â²,5â²-cyclic monophosphate; cAMP; adenosine 3â²,5â²-cyclic monophosphate; EGTA; ethylene glycol-bis(2-aminoethylether) - N,N,Nâ²,Nâ²-tetraacetic acid; H-89; N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamid
Research reportLeptomycin B attenuates neuronal death via PKA- and PP2B-mediated ERK1/2 activation in the rat hippocampus following status epilepticus
Keywords: Calcineurin; H-89; Cyclosporin A; Epilepsy; Seizure; U0126;
Growth arrest and morphological changes triggered by emodin on Trypanosoma cruzi epimastigotes cultivated in axenic medium
Keywords: Trypanosoma cruzi epimastigotes; Emodin; Cytoskeleton; Protein kinase CK2; Tubulin; Cytokinesis; Chagas disease; 2,3-BPG; 2,3-bisphosphoglycerate; DRB; 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole; KN-62; 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-ty
Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation
Keywords: BDNF; brain-derived neurotrophic factor; CAMKII; Ca2Â +/calmodulin-dependent protein kinase; CREB; cAMP response element binding protein; ERK; extracellular signal-regulated kinase; GSK-3; Glycogen synthase kinase 3; H-89; N-[2-(p-bromocinnamylamino) ethy
DAMGO depresses inhibitory synaptic transmission via different downstream pathways of μ opioid receptors in ventral tegmental area and periaqueductal gray
Keywords: 4-AP; 4-aminopyridine; AA; arachidonic acid; AACOCF3; arachidonyl trifluoromethyl ketone; AC; adenylyl cyclase; BIS I; bisindolylmaleimide I; DA; dopamine; DAMGO; [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin; DL-AP 5; DL-2-amino-5-phosphonopentanoic acid; DNQX;
Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A2A receptors and redistribution of synaptic vesicles
Keywords: Neuromuscular junction; Synaptic vesicle recycling; Acetylcholine release; Glucocorticoids; Adenosine receptors; Muscarinic receptors; ACh; acetylcholine; ADA; adenosine deaminase; DPCPX; 1,3-dipropyl-8-cyclopentyl xanthine; Dyngo-4a; 3-Hydroxy-N'-[(2,4,5
Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts
Keywords: [Ca2+]i; intracellular calcium; ADPRC; ADP-ribosylcyclase; ATP; adenosine 5â²-triphosphate sodium salt; ATPγS; adenosine 5â²-[γ-thio]triphosphate tetralithium salt; 2-APB; 2-aminoethoxydiphenylborane; BSA; bovine serum albumin; cADPR; cyclic adenosine
The TRPM4 non-selective cation channel contributes to the mammalian atrial action potential
Keywords: AP; action potential; APA; action potential amplitude; APD; action potential duration; ER; reversal potential; FFA; flufenamic acid; H-89; N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamidedihydrochloride hydrate; g; single channel conductance; H
Interactive effects of a protein kinase AII inhibitor and testosterone on spatial learning in the Morris water maze
Keywords: Testosterone; H-89; Protein kinase A; Spatial acquisition; Morris water maze
Activation of corticotropin releasing factor receptor type 2 in the heart by corticotropin releasing factor offers cytoprotection against ischemic injury via PKA and PKC dependent signaling
Keywords: CRF; corticotrophin releasing factor; CRFR; corticotrophin releasing factor receptor; MEK½; mitogen activated protein kinase; PKC; protein kinase C; PKA; protein kinase A; ACTH; adrenocorticotropic hormone; UCN; urocortin; ERK½; extracellular signal-reg
H-89 decreases the gain of excitation-contraction coupling and attenuates calcium sparks in the absence of beta-adrenergic stimulation
Keywords: H-89; Cardiac myocyte; Excitation-contraction coupling; Calcium; Sarcoplasmic reticulum; Cyclic AMP;
Reciprocal sympatho-sensory control: functional role of nucleotides and calcitonin gene-related peptide in a peripheral neuroeffector junction
Keywords: sympatho-sensory control; sympathetic transmission modulation; CGRP receptor modulation; nucleotides modulate CGRP release; ir-CGRP outflow; ADO; adenosine; CGRP; calcitonin gene-related peptide; CGRP8-37; 8-37 CGRP fragment; CRLR; calcitonin-receptor
Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate
Keywords: inflammation; lipopolysaccharide; microglia; APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl ester); chelerythrine chloride; 1,2-dimethoxy-N-methyl(1,3)benzo
Pro-inflammatory responses in human monocytes are β1-adrenergic receptor subtype dependent
Keywords: ARs; adrenergic receptors; Bmax; maximal specific binding of radioligand; CGP 20712A; [1-(2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate, 2-hydroxy-5-(2-(hydroxy-3-(4-((1-m
The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue
Keywords: Human saphenous vein; Rp-8-pCPT-cGMPS; H-89; Vinpocetine; 8-methoxymethyl-IBMX; Endothelium
Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity
Keywords: A3AR; adenosine A3 receptor; AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride; DPI; dibenziodolium chloride; ERK1/2; extracellular signal-regulated kinase 1/2; H-89; N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride;
VIP induces PKA-mediated rapid and sustained phosphorylation of HSP20
Keywords: Phosphorylation; Thin filaments; Smooth muscle relaxation; Heat shock proteins; Peristalsis; PKA; H-89;
Cyclic AMP-dependent proteolysis of GATA-6 expressed on the intracellular membrane
Keywords: cAMP; A-kinase; GATA-6; SREBP; Proteolysis; CHO-K1; BSA; bovine serum albumin; dbcAMP; dibutyryl cAMP; DIG; digoxigenine; DMSO; dimethyl sulfoxide; EEA1; early endosomal antigen 1; ER; endoplasmic reticulum; H-89; N-[2-((p-bromocinnamyl)amino)ethyl]-5-iso
Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide
Keywords: Carbon-11; PET; H-89; H-9; Protein kinase A; Signal transduction
The three-dimensional structure of human aurora-C kinase predicted by homology modeling
Keywords: Homology modeling; Aurora-C; H-89; H-8; Docking;
H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A
Keywords: 3T3-L1 cells; Adipogenesis; H-89; Protein kinase A; Rho kinase; Phosphoinositide 3-kinase; Akt; Ras; Extracellular signal-regulated kinase 1/2
Direct inhibition of a PKA inhibitor, H-89 on KV channels in rabbit coronary arterial smooth muscle cells
Keywords: Protein kinase A; H-89; Voltage-dependent K+ currents; Coronary arterial smooth muscle cells
The protein kinase A inhibitor, H-89, directly inhibits KATP and Kir channels in rabbit coronary arterial smooth muscle cells
Keywords: H-89; ATP-sensitive K+ channel; Inward rectifier K+ channel; Protein kinase A; Coronary artery
Intra-hippocampal inhibition of protein kinase AII attenuates morphine-induced conditioned place preference
Keywords: PKA; H-89; Morphine; Conditioned place preference; Hippocampus; CA1; Rat
Increase in intracellular cAMP is a prerequisite signal for initiation of physiological oocyte meiotic maturation in the hydrozoan Cytaeis uchidae
Keywords: Jellyfish; Cyclic AMP; Meiosis; GVBD; cAMP-dependent protein kinase; Umbrella-free medusa; Spawning; 8-Br-cAMP; Caged cAMP; H-89
Increase of delayed rectifier potassium currents in large aspiny neurons in the neostriatum following transient forebrain ischemia
Keywords: striatum; cerebral ischemia; neuronal death; interneuron; membrane excitability; potassium channel; ACSF; artificial cerebrospinal fluid; H-89; N-[2-((p-bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide; Ik; delayed rectifier potassium current; ISI; in
Elevation of cyclic AMP in Jurkat T-cells provokes distinct transcriptional responses through the protein kinase A (PKA) and exchange protein activated by cyclic AMP (EPAC) pathways
Keywords: EPAC; exchange protein directly activated by cyclic; AMP cyclic AMP; Cyclic adenosine monophosphate; EMSA; electrophoretic mobility shift assay; ORF; open reading frame; GST; glutathione-S-transferase; PAGE; polyacrylamide gel electrophoresis; DMEM; Dulbe
The effect of prostaglandin E1 on ion currents of NG108-15 cells
Keywords: Prostaglandin E1; Iloprost; NG108-15 cells; Rp-cAMPS; H-89; 8-pCPT-2Me-cAMP; BAPTA; Non-selective cation channel; T-type Ca2+ channel; High-voltage-activated Ca2+ channel;