کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6275973 1614879 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Delayed axonal degeneration in slow Wallerian degeneration mutant mice detected using diffusion tensor imaging
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Delayed axonal degeneration in slow Wallerian degeneration mutant mice detected using diffusion tensor imaging
چکیده انگلیسی
▶Noninvasive DTI was used to evaluate the optic nerve degeneration in the slow Wallerian degeneration (WldS) mutant mice in vivo. ▶Derived from DTI, the axial diffusivity and radial diffusivity were used to quantify axonal and myelin damage. ▶Both measures delayed for 1-2 weeks in WldS as compared with the wild-type, suggesting the neuroprotective effects of WldS gene. ▶DTI findings were confirmed by immunostaining targeting neurofilament and myelin basic protein respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 197, 1 December 2011, Pages 339-347
نویسندگان
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